P, V, & Assoc. Flashcards
Define Sexual Reproduction
Production of offspring by making germ cells
Define Fertilization
Male gamete uniting w/ female gamete
Define Gonad
Produces gametes and secretes sex hormones
Define Ducts
Store and transport gametes
Define Accessory Sex Glands
Produce substance to protect gamete and facilitate movement
As supporting structures, what do the penis and uterus assist with?
Delivery of gametes
Organs of the male reproductive system include ? 4
Testes
Ducts
Accessory sex glands
Supporting structures
What are the 6 ducts of the male reproductive system?
Straight Tubules Rete Testis Efferent Ducts Ductus Epidiymis Epididymis Ductus Deferens
What are the 3 accessory sex glands of males?
Seminal vesicles
Prostate
Bulbourethral glands
What are the 2 male supporting structure?
Scrotum
Penis
What is the external ridge of the scrotum?
Where does is start and end?
Raphe
Urethral meatus -> anus
What does the scrotal raphe represent?
Fusion of genital tubercles from embryonic development
Where does the scrotal subcutaneous layer come from during development?
Abdominal structures during embryonic development
What are the 6 layers of the scrotum?
Dartos muscle (smooth) External spermatic fascia Cremaster muscle (skeletal) Internal Spermatic fascia Tunica vaginalis (parietal and visceral)
What are the functions of the Cremaster and Dartos reflexes?
Cremaster- brings testes closer to absorb heat
Dartos- tightens scrotum to reduce heat loss
Where/how do testicles descend into the scrotum during development?
Inguinal canal during month 7 of development
What structure is a part of the scrotum AND a part of the testes?
Tunica vaginalis
Inner most of scrotum
Outter most of testicle
What does the Tunica Vaginalis develop from?
Peritoneum during descent of testes
Where/what does the Tunica Albuginea do?
Internal to T. Vagainalis
Forms septa dividing testes into lobules
What are the functional units of testes?
Lobules
200-300/testis
What are testicle lobules made up of?
Seminiferous tubules
1-3/tubule
What are the 2 types of cells found in seminiferous tubules?
Spermatogenic cells- sperm forming
Sertoli/sustentacular cells- support spermatogenesis
Where is the location of spermatogenesis?
Seminiferous tubules
Begins w/ primordial germ cell differentiating into spermatogonia
When do spermatogonia enter the testes?
What happens to them once they’re there?
5th week of embryonic development
Dormant until puberty
What is the sequence of spermatogenesis?
Spermatogonia Primary spermatocyte Secondary spermatocyte Spermatid Sperm cell (spermatozoa)
What is the purpose of Sertoli Cells in seminiferous tubules?
Embedded among speratogenic cells to support and protect spermatogenic cells
What are the 5 functions of Sertoli Cells?
Nourish spermatocyte/spermatid/sperm
Phagocyte excesses
Control release of spem -> lumen
Produce fluid for sperm transport w/in tubules since they can’t swim
Produce Androgen Binding Protein to keep testosterone in local area
What is the Blood-Testis barrier?
Tight junctions between sertoli cells w/in seminiferous tubules to isolate developing gametes from blood
What is the function of the Blood-Testis barrier?
Prevents the immune response of the spermatogenic cells surface Ags from destroying developing sperm
What are Leydig cells?
Cell in tunica albuginea around seminiferous tubules to produce/secrete testosterone
How does spermatogenesis start?
Spermatogonia that undergo mitosis from stimulation by testosterone
Spermatogonia that lose contact w/ basement membrane, pass through blood-testes barrier and differentiate into primary spermatocyte
What happens to Primary Spermatocytes after differentiation?
Meiosis 1 creates two Secondary Spermatocytes
What happens to the two Secondary Spermatocytes after meiosis one?
Meiosis II
One secondary spermatocyte= 4 spermatids after two rounds of cell division
What is the last part of spermatogenesis?
Spermiogenesis
Haploids -> sperm
Gain of acrosome, mitochondria, flagellum
Define Spermiation
When does it occur?
Sperm released from Sertoli cells into lumen
Occurs during spermiogenesis
Define Acrosome and its contents
Enzyme vesicle for penetrating secondary oocyte
Contains hyaluronidase and protease
What are the 4 parts of a sperm tail?
What organelles do they contain?
Neck- contains centrioles
Middle- contain mitochondria
Principle- longest part of tail
End- terminal
What hormones starts hormonal control of testes?
GnRH
Stimulates gonadotrophs of anterior pituitary to secrete and release LH and FSH
What is LHs influence on the testes?
Leydig cells to produce/secrete testosterone
What is testosterone synthesized from?
Cholesterol allowing it to be lipid-soluble for diffusion out of Leydig cells and into blood/seminiferous tubules
How does 5-alpha-reductase influence hormones in the testes?
Converts testosterone to Dihydrotestosterone in prostate/external genitals
What is DHTs purpose/function?
More potent androgen thought to “spark” puberty in males
Combines with testosterone to influence sexual behavior/desires
What is FHSs influence on spermatogenesis?
Indirectly
Works w/ testosterone to act on Sertoli cells to secrete ABP to keep testosterone in tubule lumen
What hormone stimulates the final steps of spermatogenesis?
Testosterone
What happens once normal levels of spermatogenesis occurs?
Sertoli cells release small amounts of inhibin which reduces the production of FSH
3 fates of testosterone and DHT during prenatal development?
Development of male reproductive system/descent of testes
DHT stimulates development of external organs
Converted to estrogen in brain for region development
Male sexual characteristics include what characteristics?
Muscle/skeletal growth Wide shoulders/narrow hips Facial/chest hair Thick skin Increase sebaceous secretions Enlarged larynx
How do testosterone and DHT influence development of sexual function?
Contribute to sexual behavior
Spermatogenesis
Sex drive
What is the main source of androgen production in females?
Adrenal cortex
What stimulates/causes males to have heavier muscle/bone masses?
Testosterone and DHT stimulate protein synthesis
How do sperm get from seminiferous tubules to the straight tubules?
Fluids secreted by Sertoli cells
Define Rete Testis
At hilum of testicle
Network of ducts that bridge straight tubules and efferent ducts
Define Efferent Ducts
Coiled ducts in epidiymis leading to ductus epididymis
Define Ductus Epididymis
Single convoluted tube connecting efferent ducts and ductus deferens
How long is the ductus epididymis if stretched out?
20ft
What is the shape and location of each epididymis?
Comma shaped organ at posterior of each testis
What is the site of sperm maturation?
Epididymis
What is the epididymis’ job during sexual arousal?
Helps propel sperm into ductus deferens
Where is the ductus deferens located?
Within epididymis where tubule becomes less convoluted and diameter increases
What are the 5 ducts of the testes?
Straight tubule Rete testis Efferent duct Ductus epididymis Epididymis
What is the path of the ductus deferens?
Transverses through spermatic cord, enters pelvic cavity, loops over ureter, down posterior surface to ampulla at seminal vesicle
Where/what is the terminal portion of the ductus deferens?
Widens into ampulla where it meets seminal vesicle
What is the function of the Ductus deferens?
Carry sperm from epididymis to urethra during arousal
Can help with sperm storage
What is the function of the Spermatic cord?
Supporting structure ascending out of scrotum with ilioinguinal nerve
What are the components of the Spermatic Cord?
Ductus deferens Testicular artery Veins Lymphatic vessels Autonomic nerves Cremaster muscle
How does the spermatic cord help with transporting testosterone into systemic circulation?
Veins carry testosterone via pampiniform plexus
Where is the Pampiniform Plexus in relation to the vas deferens?
Anteriorly
Why is more pathology found on the left side of the scrotum/reproductive system in males?
R side of pampiniform plexus drains to inferior vena cava
L side drains to left renal vein
What 2 things joins to form the Ejaculatory duct?
Union of seminal vesicle and ampulla of ductus deferens
Terminate at the prostatic urethra
What is the function of the Ejaculatory duct?
Eject sperm and seminal vesicle secretions
Male urethra is a shared terminal duct for what two systems?
Reproductive
Urinary
What are the 3 sections of the male urethra?
Prostatic
Membranous
Spongy
Where does most of the fluid portion of semen come from?
Accessory sex glands
Small part from seminiferous tubules
What are the 3 contributors of fluid portion of semen?
Seminal vesicle secretion- most
Prostatic secretion
Bulbourethral secretion- least
What are the functions of the Seminal Vesicles?
Secrete alkaline fluids to neutralize urethra and female reproductive tract
Secrete viscous fluids to keep semen in female reproductive tract longer
Seminal vesicle secretions contain what 3 things?
Fructose- energy
Prostaglandins- motility, viability
Clotting proteins- coagulates after ejaculation
What do male sex gland prostaglandins do within the female reproductive tract?
Stimulate smooth muscle contractions to aid with semen movement to ova
Prostate is located ___ to bladder and surrounds ______
Inferior
Prostatic urethra
When does normal prostate growth occur?
Slowly until puberty
Rapidly from puberty -> 30
Additional enlargement at 45 y/o
What are the 3 parts of prostatic fluid and their purposes?
Citric acid- ATP synth.
Proteolytic enzymes- break down clotting factors (specific Ags, pepsinogen, lysozyme, amylase, hyaluronidase)
Seminalplasmin- decrease number of bacteria in semen
Where are bulbourethral glands located?
Inferior to prostate on either side of membranous urethra w/ ducts opening into spongy urethra
What are bulbourethral glands role during sexyal arousal?
Secrete alkaline fluid to protect sperm and neutralize urethra
What are the 4 fluids that make up the whole seminal fluid?
Seminiferous tubules
Seminal vesicles
Prostate
Bulbourethral glands
What give semen the milky color?
What give is the viscous/tacky consistency?
Prostatic fluid- color
Seminal fluid/bulbourethral fluid- viscosity/consistency
When/why does semen coagulate and reliquify?
5 min due to seminal vesicle clotting proteins
10-20 due to prostate specific antigens
Define Hematospermia
Blood in semen
What are the 3 parts of the penis?
Body
Glans penis
Root
What are the 3 parts of the penis body?
Corpora cavernosa: 2 dorsolateral masses, fibrous tissue
Corpus spongiosum: single midventral mass w/ spongy urethra
Glans penis is the distal end of ?
Corpus spongiosum
Define corona?
Margin surrounding the anatomical glans penis
What are the two parts contained within the root of the penis?
Bulb- posterior corpus spongiosum enclosed by bulbospongiosus muscle (ejaculation)
Crura- posterior corpora cavernosa enclosed in ischiocavernosus muscle
Define Crura
2 separated and tapered portions of corpora cavernos within the root of the penis
What ligaments support the weight of the penis?
Fundiform- inferior linea alba
Suspensory- pubic symphysis
Erection is the entrapment of blood within what part of the penis?
Corpora cavernosa
Erection is by the ____ nervous system
Ejaculation is by the ____ nervous system
PS- sacral
Sympathetic- lumbar
Before ejaculation, peristatlic contraction move semen from where to where?
Epididymis Ductus deferens Seminal vesicles Ejaculatory ducts Prostate Spongy urethra
Muscles of the penis contract when stimulated by what nerve?
Pudendal nerve: bulbospongiousus, ischiocavernosus, superficial transverse perineus
How does the penis end an erection and return to flaccid?
Arterioles constrict
Smooth muscles contract
Sinuses get smaller
Pressure in veins is relieved, blood exits
Female reproductive system includes what organs?
Ovaries Fallopian tubes Uterus Vagina Mammary glands
Mammary glands are included in what two systems?
Integumentary
Reproductive
What hormones do ovaries produce?
Progesterone
Estrogen
Inhibin
Relaxin
Where/how are ovaries held in place?
Broad ligamint- part of parietal paritoneum
Ovarian- anchors ovaries to uterus
Suspensory- attaches to pelvic wall
Define Germinal Epithelium
Covers surface of ovaries
Define Ovarian Tunica Albuginea
White capsule of dense CT deep to germinal epithelium
Define Ovarian Cortex
Deep to tunica albuginea
Consists of ovarian follicles containing stromal cells
What layer of ovarian tissues are the vessels, lymph and nerves located?
Ovarian medulla
What is a graafian follicle?
Mature follicle ready for rupture/expel a secondary oocyte
Define Corpus Luteum
Remnants of follicles after ovulation
What 4 hormones does the Corpus Luteum make?
Progesterone
Inhibin
Estrogen
Relaxin
What happens to Corpus Luteums as the degenerate?
Form scar tissue called corpus albicans
How are oogonia formed during embryonic development?
4th week of development
Primordial germ cells migrate from yolk sac to gonadal ridge
At ridge, now called oogonia
What happens when oogonia undergo Meiosis I?
Change of classification from oogonia to primary oocytes
Where to primary oocytes stop in development?
Prophase of Meiosis I
Primary oocyte surrounded by granulosa cells making the structure called a primordial follicle
What does FSH/LH do to primordial follicles?
Morphs them into primary follicles
Define theca folliculi
Stromal cells surrounding basement membrane of primary follicles
What happens to primary follicles as they continue maturation?
Turns them into secondary follicles
After secondary follicle is made, what happens to the theca folliculi?
Differentiates into 2 layers
Theca internal: highly vascularized cell that secretes precursor androgen for granulosa cells to convert to estrogen
Theca externa: outer layer of stromal cells and collagen fibers
Define Antrum
Center of a secondary follicle that fills with estrogen fluid from granulosa cells
Define corona radiata
Innermost layer of granulosa cells converting into cumulus-granulosa cells that attach to oocyte
What do coronna radiata layers secrete?
Progesterone for attracting sperm and promote motility
Define Zona Pellucida?
Gel like matrix produced by oocyte to coat itself
Helps adhere cumulu-granulosa cells to it
When/where does Zona Peullucida formation start and end?
Starts in Primary Follicles
Ends as Secondary Follicles
What stage is the Corona Radiata formed?
Secondary follicle
When is a mature graafian follicle formed?
Just before ovulation of mature follicle when primary oocyte completes meiosis I, produces two cells of unequal sizes w/ 23 chromosomes
What are the names of the two cells produces at the end of Meiosis I?
Smaller- First Polar Body
Larger- Secondary Oocyte
When a secondary Oocyte is released by ovulation, how many steps of Meiosis II has it completed?
Stops in Metaphase of Meiosis II
What do the fallopian tubes do after ovulation?
Produce gentle waves to pull oocyte from peritoneal cavity to fallopian tube
Where does fertilization normally occur?
Ampulla of fallopian tubes
When sperm and secondary oocyte meet, what do they change into?
Haploid + haploid= diploid
Now called zygote
Define Anteflexion
Body of uterus projecting anteriorly over bladder
What are the 6 parts of the uterus?
Fundus- top Body- central Cervix- inferior extension of uterus Isthmus- region between body and cervix Cavity- interior of body Cervical canal- interior of cervix
What are the internal and external os?
Internal- opening into uterus
External- opening into vagina
What are the 3 layers of the uterus?
External to internal
Perimetrium
Myometrium
Endometrium
Perimetrium layer of the uterus is a part of what structures?
Visceral peritoneum
Laterally becomes broad ligament
Anteriorly covers bladder
Posteriorly covers rectum
What are the two pouches the perimetrium forms?
Vesicouterine pouch (anterior) Rectouterine pouch (posterior)
What is the most inferior location of the abdominal cavity and a site of fluid/blood collection?
Rectouterine pouch
What are the two layers of the endometrium?
Stratum functionalis- shed each month
Stratum basalis- permanent, creates new stratum each month
What is the function of the broad ligaments?
Double folds of peritoneum that attaches uterus to either side of pelvic cavity
What is the function of the Uterosacral ligaments?
Peritoneal extensions on either side of rectum that connect uterus to sacrum
What is the function of the Cardinal/Lateral ligaments?
Inferior to base of broad ligaments
Extend from pelvic wall to cervix and vagina
What is the function of the round ligaments?
CT between broad ligaments
Extends inferiorly to Fallopian tubes to external genitalia
What supplies the uterus with blood?
Branches of internal iliac artery
What arteries are in the myometrium?
Arcuate arteries
Branches of uterine arteries arranged in circular fashion
What are the branches of the arcuate arteries called and where do they go?
Radial arteries
Penetrate deeply into myometrium
What do radial arteries turn into before entering mendometrium?
Straight arterioles- supply stratum basalis
Spiral arterioles- supply stratum functionalis
Where does blood leaving the uterus empty into?
Internal iliac vein
What is the most inferior part of the uterus?
Cervix
What is the extocervix?
What is the endocervix?
External cervix and ox
Endocervical canal to internal os
Define Nulliparous Cervix
Cervix that is round, proves no fetus has passed through OR c-section was performed
Define Parous Cervix
Child has passed through cervix
Define homogenous cervix
Cervix before puberty
What might be seen on the cervix during puberty?
Endocervical cells migrating onto ectocervix
Define Vaginal Fornix
Area surrounding vaginal attachment to cervix
What anchors the vagina to the surrounding organs?
Adventitia
What allows the vagina to stretch during intercourse?
Muscularis w/ outer circular and inner longitudinal layer
What part of the vagina is continuous with the uterus?
Mucosa
The external femal genitalia is encompassed into what single term?
Vulva/pudendum
What are the 9 parts of the vulva?
Mons Pubis Labia majora Labia minora Clitoris Vestibule Skenes glands Bartholins glands Bulb of the vestibule Corpus Cavernosum
Labia majora is homologous to what male part?
Labia minora is homologous to what male part?
Scrotum
Spongy urethra
What kind of tissue makes up the clitoris?
Corpora cavernosa
What is the prepuce?
Layer of skin formed by point of labia minor
What is the exposed part of the clitoris called?
Glans clitoris
What are the 4 parts of the female vestibule?
Hymen
Vaginal orifice
External urethral orifice
Openings of ducts
Define Paraurethral glands
Skenes glands embedded in wall of urethra
Lateral to urethral orifice that secrete mucus
Define Greater Vestibular Glands
Bartholins Glands
Lateral to vaginal orifice that produce mucus during arousal
Define Corpus Spongiosum
Bulb of vestibule
2 masses of erectile tissue that capture blood during arousal to narrow vaginal orifice
Define Corpus Cavernosum
Distal portion of clitoris
What are the 2 parts of the perineum
Genitals
Anus
What are the anterior, lateral and posterior aspects of the perineum?
Anterior- pubic symphysis
Posterior- Ischial tuberosity
Posterior- coccyx
What divides the perineum diamond into smaller triangles?
Transverse line from one tuberosity to another dividing into Urogenital and Anal tirangles
Mammary glands are anterior to what two muscles?
Pec major
Serratus anterior
Define Lactiferous ducts
Closely spaced openings where milk emerges from
Why do areola take on a roughened appearance?
Modified sebaceious glands
Define Coopers’ Ligaments
Run between breast skin and fascia
How are mammary glands broken down further for milk production?
One breast contain one gland
Lobes- each gland has 15-20
Lobules- each lobe made of several lobules
Alveoli within lobules secrete milk
What stimulates production and ejection of milk?
Prroducion- prolactin
Ejection- oxytocin
Testes are homologous to ?
Ovaries
Sperm is homologous to ?
Ovum
Scrotum is homologous to ?
Labia majora
Spongy urethra is homologous to ?
Labia minora
Corpora cavernosa is homologous to ?
Clitoris
Corpus spongiosum/penis bulb/glans is homologous to ?
Bulb of vestibule
Prostate is homologous to ?
Skenes glands
Bulbourethral glands are homologous to ?
Bartholins glands
Female reproductive cycle involves what two parts?
Ovarian cycle
Uterus cycle
Hormones from what 3 places control female reproductive cycle?
Hypothalamus
Anterior pituitary
Ovaries
What are the two cycles that make up the female reproductive cycle?
Ovarian cycle
Uterine cylce
Define ovarian cycle
Changes that occur during and after maturation of oocyte
Define uterine cycle
Changes in endometrium to prepare it for implantation
If implantation doesn’t occur, _____ retreat causing sloughing of _____
Ovarian
Stratum functionalis
Female GnRH controls what part of reproductive cycle?
Both ovarian and uterine
Where is GnRH released from and what does it do?
From hypothalamus
Stimulates release of LH and FSH
Stimulates ovarian follicles to produce estrogen
What does FSH cause to happen?
Initiates follicular growth
Androgen from LH taken up by granulosa cells and turned into estrogen
What does LH stimulate?
Development of ovarian follicles
Theca cells to produce androgens
Ovulation
______ forms the corpus luteum
LH
What does the Corpus Luteum produce and secrete?
Progesterone
Inhibin
Estrogen
Relaxin
Estrogen promotes development and maintenance of ?
Reproductive structures
Breasts
Protein anabolism
Lower blood cholesterol
Progesterone is secreted mainly by ? cells
Corpus luteum
Small portions by cumulus cells around an ovulated oocyte
_____ helps prepare mammary glands for milk secretion
Progesterone
High levels of progesterone inhibits secretion of ____ and _____
GnRh
LH
Functions of relaxin
Inhibits contractions
Increases flexibility of pubic symphisis
Dilates cervix
Functions of inhibin
Secreted by granulosa cells (growing follicles) and corpus luteum (post-ovulation)
Inhibits secretion of FSH and LH
What are the 4 phases of the female reproductive cycle?
Menstrual
Preovulatory
Ovulation
Postovulatory
What day marks the first day of a new cycle?
1st day of menstruation
What phases make up the follicular phase?
What phases make up the luteal phase?
Menstrual + preovulatory
Ovulation + postovulatory
Preovulatory phase = ____phase
Proliferative
Post-ovulatory phase=______ phase
Secretory
Secretion of glycogen by secretory glands of endometrium
What is occurring in the ovaries during the menstrual phase?
Increased FSH causes transition of primordial follicles into primary follicles
What is occurring in the uterus during the menstrual phase?
Declining levels of progesterone and estrogen causes release of prostaglandis
Prostaglandins cause spiral arterioles to constrict and die
Stratum functionalis soughs off
What is occurring in the ovaries during the preovulatory phase?
Primary follicles have matured into secondary follicles and start secreting estrogen and inhibin
Dominant follicle releasing estrogen and inhibin causes decrease of FSH released
Dominant follicle->graafian follicle
What events are occurring in the uterus during the preovulatory phase?
Estrogen from growing follicle enters blood and causes repair to endometrium
Stratum basalis does mitosis and produces new stratum functionalis
Endometrium doubles in thickness
What events are occurring in the ovaries during the ovulation phase?
Graafian follicle released into pelvic cavity
Secondary oocyte surrounded by zona pellucida and corona radiate
High levels of estrogen from pre-ovulatory phase causes positive feedback for LH and GnRH, causes ovulation
What events are occurring in the uterus during the ovulation phase?
Lining continues to proliferate
Arterioles lengthen, coil and embed into endometrium
At home ovulation kits can detect LH surge during what phase of the reproductive cycle?
Ovulation phase
What events are occurring in one ovary during the post-ovulatory phase?
Basement membrane between theca interna and granulosa cells breaks down to become corpus luteum after influence of LH
What hormones causes corpus luteum to start producing and secreting it’s 4 hormones?
LH
What happens in an ovary during the post-ovulatory phase if fertilization doesn’t occur?
Corpus luteum lasts for two weeks until declining hormones cause degeneration into corpus albicans
Lower PIER levels cause increased GnRh, FSH and LH
Follicular growth resumes and new cycle begins
What happens in one ovary during the post-ovulatory phase if fertilization does occur?
Sperm penetrates zona pellucida causing oocyte to complete Meiosis II
What events occur in the uterus during post-ovulatory phase?
Progesterone and estrogen from corpus luteum causes growth and coiling of endometrial glands, vascularization and thickening of endometrium
What are the 4 phases of the female orgasm?
Excitement Phase- parasympathetic response
Plateau Phase- parasympathetic
Orgasm Phase- sympathetic
Resolution Phase- sympathetic
What is the Essure birth control method?
Coil inserted into fallopian tubes causing scarring and prevents secondary oocyte from traveling down tubes
Where do IUDs sit inside of the uterus?
Into internal Os
What causes menopause?
Estrogen decline
Hot flashes/sweating from GnRH surges
Define Benign Prostatic Hyperplasia
At 60 y/o, normal prostate enlargement
What does the word vulva mean?
To wrap around