OB Cram Flashcards
Cyst size for Premenopause women and management
3cm or less: norm variant
5cm or less: no Tx
5-7cm: repeat TVUS 12 wks, persistant= annual
+7cm: MRI/surg eval
Cyst size for Post-menopause women
1cm or less: norm variant
5cm or less: CA125 level, norm= repeat TVUS 12 wks, perisitant= annual
>7cm: MRI/surg eval
Risk factors for Endometrial CA
Nullparity
Obese
PCOS
Estrogen
White
Infertile
DM/CHTN/Gallbladder dz
Early menarche
Late
Irregular
North american/european
Tamoxifen
COC w/ smoking
Old
What is the primary driver of endometrial cancer risk
Paps stop at ? age
AGC Pap result management
Estrogen exposure length
65
Colpo and endocervical/metrial sampling
No concern for HPV status
Post menopause PT w/ HTN, DM and PCOS w/ vaginal bleeding x 2wks, what is next step?
When is endometrial ablation used for Tx
Hysteroscopy
AUB w/ reproduction complete
Endometriosis Tx concurrent w/ laproscopic exam
When is Uterine Artery Embolization used for Tx
AUB, acute menorrhagia if balloon tamponade fails
Leiomyomatas
Leiomyoma
MC pelvic tumor in women that are Estrogen dependent
Round/rubbery
Present: bleeding, pressure, pain, infertility
Dx: US
Tx: COCs (dec bleeding) UAE Hysterectomy
Adenomyosis
Endomettriosis in myometrium
Present: Heavy bleeding or Dysmenorrhea in parous women 40-50y/o
Dx: TVUS, MRI
Tx: Hysterectomy Progestin IUD Danadol COC GnRH agonist
Polyps
MC Sx: mentrorrhagia
Dx: TVUS, Sonohystography
Tx: if Sx/Large, remove
Endometrial Hyperplasia
From recurrent/chronic annovluation due to unopposed estrogen
MC presentation: AUB in post-menopause female +50
Dx:
Pre-Meno: biopsy, Gold Standard
Post-Meno: TVUS= Dx equivalent, <4mm= low risk
What classification of endometrial hyperplasia has the highest/lowest chance for progressing to Ca?
How are atypia cases Tx
Most: Complex hyperplasia w/ atypia
Less: Simple hyperplasia w/out atypia
Post menopause, no kids: hysterectomy w/ BSO
Pre-meno atypia, wants kids: progestin, EMB q3mon
How are endometrial hyperplasia cases w/out atypia Tx
Pre-meno: progestin or COC w/ q3-6mon EMB
Inc progesterone or refer to hysterectomy
Post-meno: COC/progestin w/ EMB q3-6mon
Endometrial Ca
MC Gyn Ca in US
MC Sx: vaginal bleeding
Sx: Pressure Irregular bleeding Girth Satiety Bloat
Dx: EMB
Post-Meno w/ stripe 5mm or more= biopsy
D&C if biopsy c/i or persistant bleeding w/ normal biopsy
Tx: Hysterectomy w/ BSO and lymph node staging
HT w/ progestin (Tamoxifen)
What Ca condition may require a hysterectomy as prophylaxis
PTs w/ this need to have ? screening procedure started at ? age
Lynch Syndrome
30-35y/o: EMB Q1-2yrs
How is endometrial Ca Tx if fertility is trying to be spared?
Dx hysteroscopy
D&C sample
Hormone Tx
Functional Cyst
> 3cm in woman of reproductive age
Sxs: dull pain, heaviness
Hemorrhagic cyst- inc Sxs
Dx: bimanual exam, US
Cyst + Pain= surg eval
MC epithelial benign neoplasm
What is the largest
? is MC benign ovarian neoplasm
Serous cystadenoma
Mucinous cystadenoma
Benign Cystic teratoma: Germ cell
PT w/ ovarian mass may have ? key Sxs
Weight loss
Ascites
Pleural effusions
Bimanual
US
CA-125- if Post-Meno
Dx w/ biopsy
Complex cyst management
Ovarian Torsion
Pre-Meno: TVS in 12wks, perisistent= MRI/surg eval
Post-Meno: surg eval
Twisted adnexal component: ovary and tube
Highest rate: adnexa 6-10cm
R more common, L protected by sigmoid
Steroid hormones cause maleness
DHEA: adrenal- weak
Androstenedione: adrenal, ovary- weak
T: adrenal, ovary, adipose- potent
DHT: follicle, genital skin- most potent
Hypertrichosis
Hirsutism
Virilization
Genetic variant, not due to androgens
Terminal hair in male patterns, due to androgens
Acne, baldness, hypertrophy, due to androgens
PCOS
Inc androgens and estrogen
Sxs: Hirsutism AUB PCOs Infertile Obese
Dx: hyperandrogen, olio/anovulation
Ovarian Hyperthecosis
Leutenized theca cells
Balding Hypertrophy Deep voice
Inc insulin resistance
Acanth Nigrans
HAIRAN
Hyper Androgen Insulin Resistant Acanth Nigrican
Hyperandrogen
Severe insulin resistance