Pediatrics: Block 1 Flashcards
What two phases is the prenatal period divided into?
What period overlaps the Prenatal and Postnatal periods?
Embryonic- first 8wks
Fetal- after 8wks of gestation
Perinatal- 20-28wks of gestation through 1-4 weeks after birth
Define Perinatal Mortality
What are the two most common causes of it?
Fetal death between 20wks EGA through 28 day pos-delivery
Congenital abnormalities
Prematurity <37wks
What is the range for normal respiration for newborns?
What is the range for normal heart rates? What ranges are indicative of necessary interventions needed?
30-60/min
120-160
>100: routine care
60-99: ventilation
<60: ventilation and chest compressions
What is the correlation between pediatric age, HR, BP and R?
How many chest compression and compression/breath ratio during NRP?
As they get older HR and RR decreases, BP increases. “Adult-like” around 12 y/o
120bpm
3 compression : 1 respiration w/ two thumbs method (preferred) or two finger method
When placed supine on tables, what breathing position do babies take?
When administering O2 to newborns by blow by, how much is used?
Sniffing position
Blow by= 10L/min @ < 1/2” from face
BVM= sniffing position @ 40-60/min
Intubated= done if no chest rise/fall w/ BVM and allows for med delivery and preferred for transport
What is done for neonatal HOTN?
What drugs are given for HR?
What drugs are given for opioid use/abuse?
10mL/kg NS or LR
Epi 0.1-0.3mL/kg or 1 : 10,000 for IV/ETT for Asystole/Brady and unresponsive to O2
Narcan- narcotic/opioid reversal 0.1mg/kg IV/IM/ET
DONT if mom is addict/methadone, leads to withdrawal seizures
USE if mom received opioids/short term use during delivery
What type of issues are seen in Hemorrhagic Disease of Newborns?
Generalized echymosis
GI bleeds
Umbilical stump bleeding
Circumcision bleeding
If baby is bottle fed, what does the formula need to contain when 4-6mon of age is reached?
Fe- deficiency risk starts at 4mon,
Starting @6mon: 1mg/kg/day, max 15mg
Vit D- 400 IU/day for first days of life; deficiency= rickets, most common in first 2yrs of life
What are the results of rickets in babies?
Craniotabes- thin skull, fells like ping pong ball
Thickened wrists/ankles
Rachitic Rosary- costochondral junction enlargement
Enlarged anterior fontanelle/delayed closure
Bow leg/knock knees
During a newborn exam, what does an enlarged anterior fontanelle greater than 5cm suggests ? issue
Define Craniosynostosis
Hypothyroidism
Closed fontanelles
Define Leukocoria
During newborn exams, how would congenital heart d/os present?
White reflex in the eye
Can be cataract, retinoblastoma, chorioretinits, hyperplastic primary vitreous, retinopathy of prematurity
Systemic Sxs, murmur may not be heard
What are the negative, false result and positive screenings for pulse oximetry for newborn screening and what are the next steps?
All 3 done at 24hrs of life or shortly before discharge
95% or more on R hand/foot w/ 3% difference= negative screening, plan for discharge
90-94% and 3% or less difference= repeat screening in 1hr. If repeat results are in low range, repeat again in 1hr. 3 readings in this range need echo
<90% in R hand or foot= positive screening result, Echo
What do each of the following findings during a newborn exam indicate? Weak pulse Bounding pulse Single second heart sound Continuous harsh holosystolic murmur Grade 3 or higher murmur Hepatomegaly
Poor CO- aortic stenosis High CO- PDA Cyanotic HDz- truncus arteriosus, hypoplastic left heart Pathologic Pathologic Pathologic L HF
Newborn exam should show a soft and round abdomen, what does a scaphoid shape mean?
Define Barlow and Ortolani maneuvers
Diaphragm hernia
Hip dysplasia indicator test
Ortalani- clunk of hip relocating anteriorly
What are the risk factors of congenital hip dysplasia
How is it evaluated?
Female, FamHx, Breech, First born, Oligohydramnios, Post natal swaddling
US suspicious findings or risk factors @ 4-6wks old
When are the following reflexes gone by Fencer/Asymmetric neck reflex Trunk Incurvature/Galant Placing Rooting- turns cheek to stimulus Moro Grasp Babinski
3mon 4mon 4-6mon 4-6mon 6mon 6mon 12-28mon
Define Caput Succedaneum
Define Cephalohematoma
Common boggy edematous swelling of scalp that crosses suture lines and resolved in 3 days
Less common swelling that doesn’t cross suture lines and resolves in wks/mon but can lead to jaundice
Define Subgaleal Hemorrhage
Rare subaponeurotic bleeding result of vacuum delivery that crosses suture lines and pushes ears anteriorly and increases risk of jandice; Tx by compression and resuscitation
Define Epstein Pearls
Define Vernix Caseosa
Keratin cysts, resolve in first weeks
Salivary tissue- Bohn nodules
Chalky white/gray mixture of epithelial cells, sebum, keratin and hair
Common in pre-terms
Thought to be protective/lubricant in womb
Define Milia
Define Milia Rubra
White smooth papules on face/scalp from epidermal occlusion of pores
Self limited and resolving
Overheated/febrile heat rash as erythematous papules
Tx by correcting over heating
Define Mongolian Spot
Define Cafe Au Lait Macules
Blue/black pigments on lower back/butt in AfAm/Asian/Indian infants that fades in life
Must be documented
Sharply defined oval macules/patches
6cm or larger Cafe or 5cm or larger diameter need further eval of neurofibromatosis, tuberous sclerosis, McCune-Albright Syndrome
Define Nevus Simplex
Define Nevus Flameus
AKA Salmon Patch
Stork bite- nape of neck
Angel kiss- forehead/eyelid
Transient and benign
Port wine stain from malformed capillary bed
Must consider Sturge-Weber Syndrome on face (trigeminal nerve distribution)
Define Erythema Toxicum Neonatorum
Define Neonatal Acne
Pustules w/ erythematous base appearing on back and trunk 24-48hrs after birth that lab results will show eosinophils and resolves in 2wks
Acne on cheeks/scalps in first few weeks of life from maternal estrogen
Define Cutis Marmorata
Define Cradle Cap
Mottling
Physiologic response to cold, resolves w/ warmth that decreases w/ age
If persistent: hypothyroid, vascular/congenital issue
Seborrheic Dermatitis
First sign of atopic dermatitis
Can treat resistant/persistant cases w/ mineral oil, white petrolatum emollient or medicated shampoo
Define Umbilical Granuloma
Red papule from umbilical stumps and resolved w/ silver nitrate Distinguish from: Urachus- urinary d/c Meckels Vitelline Duct Talc granulomas
Define Metatarsus Adductus
Most common foot disorder in infants
Medial deviation of mid and forefoot, can lead to hip dysplasia
Dx- mid-heel bisector line should go between toe 2 and 3; V-finger should not gap at 5th MT
Tx- most spontaneous, serial casting, bracing, surgery
Define Talipes Equinovarus
Clubfoot, Limp Hypoplasia Calf atrophy and foot shortening, half are bilateral Congenital- 75% of cases Teratological- myelomeningocele Positional from in utero Tx w/ serial cast or surgery
Define Spina Bifida
Lumbosacral neural tube defect, Cleft Spine
Dx during 2nd trimester from maternal AFP and US
Rachischisis- hair tuft
Meningocele- meninges through neural arch
Meningomyelocele- meninges and cord through arch
Myeloschisis- open skin, cord exposed
How can spina bifida be prevented during pregnancy?
Facial pasly after birth is indicative of ?
Folate
Forcep delivery
Define Erb-Duchenne Palso
C5-6 and Phrenic nerve lesion \+ Grasp reflex - Bicep reflex Waiter tip palsy From difficulty delivery- shoulder dystocia Resolves w/ PT and observation
Define Klumpke’s Palsy
C8-T1 lesion - Grasp reflex \+ bicep reflex Claw hand Ipsilateral Horner's Syndrome
What are the two types of hydrocephalus
Communicating- w/ subarachnoid
Non-communicating- obstructed
Tx w/ Ventriculoperitoneal shunt
What are the risk factors of neonatal sepsis
Prematurity- 6x greater Prolonged membrane rupture GBS Maternal fever Amnionitis Fetal tachycardia
What are the common etiologies of early onset neonatal sepsis
What are the causes of late onset?
GBS, E Coli, Klebsiella, Listeria M., Salmonella, Mycoplasma
H Influenzae, Staph, HSV, CMV, Enterovirus, S Pneumo, N. Meningitis
What is early onset neonatal sepsis
What is late onset?
0-7 days old; fast onset and quick progression to severe Sxs: fever, hypothermia, HOTN, Resp Distress
8-28 days old; isidious onset w/ fever, poor feeding, lethargy, bulging fontanelle, poor muscle tone, seizures, direct hyperbilirubinemia; more likely associated w/ meningitis
What labs are ordered to evaluate neonatal sepsis?
CBC, Cultures x 2, UA, Urine culture, Blood glucose
CXR
LP for culture, stain, protein and glucose
How is neonatal sepsis treated?
IV Ampicillin and Gentamicin or; Ampicillin and Cefotaxamine Draw labs and continue until: - culture results Sepsis confirmed- 14 day Tx Meningitis confirmed= 21 days Tx
What two ABX can be added to neonatal sepsis treatment
Vancomycin- if late onset of miningitis is present
Acyclovir- concern for HSV infection
Support- IV fluid, nutrition
What are the 3 steps for GBS treatment of the mother?
1- infant Sxs; yes= full eval and empiric Tx
2- child <35wks EGA; yes= limited eval and 48hr observation
3- mother receive 2 ABX doses prior to delivery; yes= no eval or therapy, observe 48hrs
RDS is AKA and is what issue?
Hyaline Membraine Dz Insufficient surfactant production by Type 2 Pneumatocytes Commonly seen <34 wks EGA Ends w/ End-Expiration Atelectasis CXR shows bilateral ground glass
How can RDS be prevented prior to birth?
How is it treated after birth?
Steroids at 32-34wks
Intubation and respiratory support by artificial surfactants via ET tube
Define PDA and what type of issue is it
How is it treated?
L to R shunting from high to low press that becomes apparent 2-4 days of life but can result in HF, pulmonary edema or hepatomegaly
Fluid restriction and diuretics
Indomethacin or Ibuprofen
What causes Bronchopulmonary Dysplasis and how is it treated?
O2 toxicity/barotrauma Presents as required O2, Poor Growth, Hypercapnea, PHTN, R HF Inc risk in those who: O2 dependence at 36wks RDS fails to improve after 2wks Prolonged mechanical ventilation
What causes Retinopathy of Prematurity
Acute and Chronic effects of O2 toxicity
Leads to neovascularization, retinal detachments or fibrous proliferation behind lens
What are the 2 types and causes of Premature Apnea
How is it treated
Central- medulla and pons don’t stimulate phrenic nerve (majority but usually has peripheral component too)
Peripheal- airway obstruction
O2, Caffeine/Theophylline, Anemia Tx
Define Tracheomalacia
Weak/floppy tracheal cartilages
Worsens: cry, cough, feed or URIs
Possible high pitch/rattling noise
What 4 issues can develop into Meconium Aspiration Syndrome
What delivery airway interventions are done?
Respiratory distress, Pneumonia, Pneumonitis, Pneumothorax
Nonvigorous child= intubate and suction
Vigorous- no routine intubation or suction
How does MAS look on CXR?
Coarse irregular infiltrates
Predisposed to chemical/bacterial pneumonia and pneumothorax
What causes Transient Tachypnea of Newborns?
Retained amniotic fluid causing mild hypoxia and resolves in 24hrs
CXR shows fluid in fissures
More common in C-Section or LGA infants since they don’t get squeezed during delivery
What are the two types of PHTN
Primary- hypoxia w/out cardiac/pulmonary dz; normal CXR; inherited/autoimmune, drugs
Non-Primary- result of other process PFO, PDA
What is the most common cause of neonatal anemia
What test is done to assess anemia from maternal-fetal hemorrhage?
ABO incompatibility
Kleihauer-Betke test
What is the most common cause of neonatal jaundice?
Define Breastfeeding Jaundice
Define Breast Milk Jaundice
Hemolytic Dz of newborns
Insufficient milk production/ingestion
Unknown milk factor that inhibits bilirubin conjugation or enzyme that enhances bilirubin absorption
Characteristics of Physiologic Pattern Jaundice
Characteristics of Pathologic Patter
Evidence of jaundice starting when Bili levels get to 5-10; starts on face and moved to trunk, concerning if past umbilicus
Term= 12 or less on day 3
Pre= 15 or less on day 5
Early /fast, >13mg/dl on day 1 (always pathologic), jaundice set in within 24hrs
Hepatosplenomegaly and Anemia
Inc of >0.5mg/dl/hr, onset within first 24hrs and peak over 12= abnormal
What can cause Physiologic Jaundice
Insufficient UDPGT activity= no conjugation Insufficient intestine bacteria Dec intestine motility Altitude- +3100m Race- Asian, Greek Premature Breast feeding
What causes Breast Milk Jaundice
Adequate intake
Fatty acids displace bilirubin from albumin (unconjugates)
Factor enhances intestinal bilirubin
Occurs 7-10 days after birth
Unconjugated hyperbilirubinemia w/out hemolysis
Bilirubin rarely rises above 20mg/dL
What labs are ordered for Neonatal Jaundice
Total bili CBC, Blood type Coombs- tests for Abs on RBCs Peripheral smear Retic count Test G6PD deficiency
Define Kernicterus
Bilirubin Encephalopathy
Lipid solube, unconjugated indirect bilirubin that accumulate and are CNS toxic
Usually does NOT develop in term infants but are predisposed if other issues are present
How does Kernicterus manifest clinically
Early: Lethargy, Hypotonia, Irritable, Poor Moro response, Poor feeding, High pitch cry usually seen on day 4 of life
Late: bulging fontanelle, opisthotonic posturing, pulmonary hemorrhage, fever, hypertonicicty, paralysis of upward gaze, seizure
How are different severity of neonatal jaudince treated?
Mild- lifestyle changes, increase feeding, sunlight
Moderate- phototherapy
Severe- transfusion (indirect Bili @ 20 in infants w/ hemolysis and weight +2000g; indirect Bili >25 in ASx infants w/ physiologic or breast milk jaundice
What are the adverse effects of neonatal phototherapy?
Short: Diarrhea, interfered bonding, intestinal hypomotility, temp instability
Long: Childhood asthma, Type 1 DM
What are the timing intervals for jaundice evaluation of healthy term neonates post-hospital discharge
Discharged before:
24= 72hrs
24-47.9= 96hrs
48-72= 120hrs
What are the age ranges for Neonate, Infant, Toddler, Pre-Schooler, Child, and Adolescent?
N 0-28 days I 29-1y T 1-3y P 2-5y C 1-12y A 13-18y
What are the criteria for underweight, normal, overweight and obese
Under= <5th percentile
Normal= 5-85th
Over= 85-95th
Obese- >95th
During childhood, what part of growth typically doesn’t cross percentile lines?
When does sigmoid shaped growth occur?
Height
Adolescence, accounts for 15% of adult height
How does weight change from day of birth to first year of life
5-10% of birth weight lost in first few days
Return to weight by day 14
Double 4-5mon
Triple- 1yr
Daily gain- 20-30g first 3-4mon; 15-20g for rest of first year
Average baby length is _in at birth and _in by 1st year and _in by 4yrs
What is the average head circumference
20, 30; double birth length or 40in
35cm at birth
Inc 1cm/mon for first year; 2cm/mon for first 3mon then dec
How long are head circumference serial measurements taken?
When do abnormal growth patterns require action to be taken?
Until 2yrs old
Infant <5% w/ no obvious cause
Infant crosses two percentiles or major channels w/out cause
Large discrepancy between head circumference, height, weight
In general, half of a child’s growth occurs during ?
Babies that are small for gestational age or are premature do catch up growth when?
First 2yrs of life and usually remains in the same channel
First 6mon
What is the mid parental method of height prediction equations?
What is the 2 year x 2 method equation:
What is the most accurate method
Male: Dad + Mon/2 + 2.5
Female: same but -2.5
Inches at 2 x 2
Bone age- xray of hand
What are the 5 developmental areas assessed during ASQs?
When is DDST-II used?
Communication, Gross motor, Fine motor, Problem solving, Personal-Social
0-6yrs, assesses 4 areas: Personal-Social, Fine motor-adaptive, Language, Gross motor
What is the M-CHAT
Modified Checklist for Autism in Toddlers
Autism Screening done at 18-24mon that checks 23 behaviors
> 2 predictive or >3 total behaviors require additional assessment
What milestones are seen at 2wks old?
Gross motor: moves head side to side
Personal social: regards face
Language: alerts to bell
What milestones are seen at 2mon old?
Gross motor: lifts shoulder when prone
Fine motor: tracks past midline
Personal social: smiles responsively
Language: cooing, searches w/ eyes
What milestones are seen at 4mon old?
Gross motor: lifts up on hands, rolls f-to-b, no head lag
Fine motor: reaches, raking grasping
Personal social: looks at hands, works towards toys
Language: laughs and squeals
What milestones are seen at 6mon?
Gross motor: sits alone
Fine motor: transfers objects in hands
Personal social: feeds self,
Language: babbles
What milestones are seen at 9mon?
Gross motor: pulls to stand, seating postion
Fine motor: pincer grab, bangs blocks together
Personal social: waves by, plays patty cake
Language: says non-specific two syllable words
What milestones are seen at 12mon?
Gross motor: walks, stoops and stands
Fine motor: puts blocks into cups
Personal social: drinks from cups, initiates others
Language: says mom/dad and one/two other words
What milestones are seen at 15mon?
Gross motor: walks backwards
Fine motor: scribbles, stacks blocks
Personal social: uses spoon/fork, helps in housework
Language: says 3-6 words, follows commands
What milestones are seen at 18mon?
Gross motor: runs
Fine motor: kicks ball, stacks 4 blocks
Personal social: removes clothes, feeds dolls
Language: says 6 words
What milestones are seen at 24mon?
Gross motor: goes up and down stairs Fine motor: stacks 6 blocks Personal social: washes/dries hands Language: puts two words together Other cognitive: understands concept of 'today'
What are the red flags of gross motors are concerning if seen at certain time frames?
Rolling prior to 3mon= increased tone
Poor head control by 5mon= hypotonia
Lack of sitting by 7mon= hypotonia
Hand dominance before 18mon= contralateral neuromotor abnormality
What are the red flags of language development?
1st think hearing Failure to vary voice pitch by 4mon Lack of babble/localizing sound by 6mon No true words/gestures by 15mon No protodeclarative pointing by 18mon Less that 50% intelligible speech by 2yrs
All kids with speech delay get what series of exams?
Visual exams are performed at every visit until what age?
Tympanometry, Audiometry- Auditory Brain Stem Response to r/o peripheral hearing loss
2y/o
When do general exams occur in peds lives?
Normal development should show what type of BP by 3yrs old?
3-5 days, 2wks
Mon= 2 4 6 9 12 1 5 18 24 then annual
SBP= 80 + (age x 2) DBP= 2/3 of SBP
What is one growth marker/assessment that is conducted at every appointment?
What screening tests are performed on kids?
Obesity
Metabolic, Hgb Electrophoresis, Hearing eval
When are anemia screenings conducted?
How much lead does it take to cause learning issues?
12mon if healthy, 4mons if at high risk
5-10 ug/dL, screened at 12 and 24mon
Screening questions from 6mon-6yrs, may be required prior to starting Kindergarten
When is TB screening conducted?
When are kids lipid panels assessed?
After 12mon
9-11yrs and 17-21yrs
If parents have Cholesterol >240 or premature CAD, start at 2y/o
Normal total cholesterol <170
How often are STI screenings done and what is tested for?
When are Paps and HPV done?
Annually after any form of intercourse
G/C, syphilis, Hep B and HIV
21y/o
Define Active Immunity
Define Passive Immunity
Induces immunity from vaccine/toxoid (inactivated toxin)
Induces transplacental transfer of maternal Abs and administration of Ab (immunoglobulin or monoclonal Ab)- breast feeding
How often are premature babies vaccinated?
Regardless of weight, same chronologic age/schedule as full term kids
ONE exception- Hep B for <2000g; if mother is Hep B surgace Ag negative then give at 1mon instead of birth
When are adolescents given vaccines?
Which vaccine has mercury and why is it of concern?
11-12yrs of age w/ completion of series by 13-18yrs
N Meningitides booster at 16yrs
Thimerosal- trace amounts found in flu vaccine but was banned in 2001 and autism cases have increased
What is the Hep B series
3 doses, 1st dose at birth/within 24hrs
Exception, underweight <2000gm
What is the DTap Series
5 doses given at 2 4 6 and 15-18mon and 4-6yrs old
1 adult dose at 11-12y/o
What does the HIB series prevent?
What was the IPV series discontinued?
Reduces risk of meningitis and epiglottis
Only known cases of vax-induced polio in US
What is MMR given?
When is MCV4 (Menactra) given?
Mumps- resurgence in adolescents
Rubella- prevent fetal malformation
Measles- from overseas
Meningococcal, given 11-2y/o or prior to college
Consider at 2-10 if splenc disfunction/immunocompromised