Derm Block 3 Flashcards
Staph A morphology and staining pattern
If this microbe infects the skin, what four infections can it cause?
The elaboration of these toxins can lead to ?
Gram + Cocci
Cellulitis Impetigo Folliculitits Furuncles
Bullous impetigo
SSSS
? are the secondary invaders of traumatic skin lesions
What four infections can it cause upon infecting the skin?
Group A B-hemolytic strep- Gram + Cocci
Lymphangitis Impetigo Cellulitis
Erysipelas
What causes Non-Bullous Impetigo
How does it start and what does if classically look like
This condition is more common in ? PT populations and frequently co-infected w/ ?
GABHS
Stratum Corneum pustule, ruptures to honey crusted lesion w/ regional adenopathy
2-5y/o Peds in warm/moist climates
Staph
How is Non-Bullous Impetigo Tx
If ABX are used, what is the purpose of their use
Soak, removes crust
Local: Topical Mupirocin
Wide: Diclox/Cephalexin
Prevent acute glomerulonephritis after impetigo
What causes Bullous Impetigo
What PT population is this MC in
How is this form different?
Staph impetigo
Infant/adolescent
Less exudative crusting- center collapses w/ tube-like rim
How is Bullous Impetigo Tx
If PTs have recurrent cases of impetigo, what test needs to be ordered?
Local: Mupirocin
Wide: E/C-mycin Diclox Cephalex
Staph A carrier, Tx w/ Mupirocin
Cellulitis is a skin infection that extends to ? layer
How does it present
What are the microbe etiologies
Into SQ
Erythema Edema Pain
GABHS- MC
Pseudomonas in DM
Staph
H influenza
What parts of the body are more likely to be the portal of entry for cellulitis microbes?
How does cellulitis present in clinic?
Compromised areas by stasis/lympedema
Warm Adenopathy Red Tender Swollen w/ poor defined border
Streaks= lymphangitis
How are cellulitis PTs Tx outpatient
How are they Tx inpatient
How are DM w/ Pseudomonas Tx
How are PTs w/ H influenza Tx
Compress/Elevate
Diclox/Cephalexin/Clinda/TMP
Nafcillin
Vanc if PCN allergy
Aminoglycosides
Cephalosporin
Define Erysipelas and what microbe causes it
Erysipelas is AKA ?
Superficial cellulitis of lymphatics from Strep Pyogene
St Anthoneys Fire
How does Erysipelas present and what makes this presentation different
How is Erysipelas Tx
Sharp demarcated, raised plaque w/ pain/erythema on
face, ears, legs after 48hr prodrome
PO: Cephalexin Amox/Diclox
IV: Cephazolin Ceftriaxone
Define Blistering Distal Dactylitis
How is it Tx
Superficial infection of anterior finger pad MC 2-16y/o
InD w/ Anti-Strep ABX
Define Folliculitis
What is the MC form of infectious folliculitis
Define Superficial Folliculitis
Inflamed hair follicle from infection, chemicals or injury
Staph, common in nares or areas of occlusion
Perifollicular pustules w/ undamaged hair in center
How is folliculitis worked up
How is it Tx
What adjunct can be added for Tx
Culture pustule- scrape pustule off w/ 15 blade onto swab
Removal, hygiene
E/C-mycin Diclox Cephalexin
Benzoyl Peroxide (keratolytic, anti-bacterial)
How is persistent/deep folliculitis (sycosis barbae) Tx
If folliculitis is in the scalp and present long term, Tx PT for ?
Systemic ABX
Folliculitis decalvans
Define Sycosis Barbae
How is it Tx
What is done for PTs that have resistant cases or are Tx failures?
Inflammation of whole follicle, Staph Impetigo of beard
Local: Mupirocin
Wide: E/C-mycin Diclox Cephalex
Eval for dermatophyte infection
w/ hair removal, culture
Define Furuncle
Define Carbuncle
Where do both of these have in common?
Boil/abscess, walled collection of pus w/ pain
Multi-headed boil, associated w/ cellulitis
Painful perifollicular infections on traumatic areas of skin
How are furuncles/carbuncles Tx
Recurrent furuncles are commonly infected w/ MRSA and Tx w/ ?
How is MRSA furunculosis Tx
InD
ABX if cellulitis is present
Mupirocin
Chlorhexidine/bleach bath
Culture dependent: Clinda/TMP
What causes SSSS
Dec function of ? organ allows for toxins to accumulate?
How do the toxins spread in the body?
Staph A exfoliative toxins
Dec renal clearance
Hematogenously
SSSS typically starts as ? presentation in kids
What does the prodrome of this syndrome present as
Bullous impetigo
Malaise Fever Irritability
Skin tenderness
If mild case of SSSS presents and is going to be Tx on outpatient basis, what ABX are used?
Pseudomonas usually infects ? PTs in ? locations
B-lacatm resistant- Diclox, Cephalexin
DM
Warm/moist
What PE finding is indicative of Pseudomonas
What does this smell like?
Pyoverdin- light green pigmentation w/ woods lamp
Fruity/grape like
Define Hot Tub Folliculitis
These PTs are at low risk for ?
How are they Tx
8hrs-5d after exposure
Pruritic round, urticarial plaques w/ central pustule
Sepsis
Antihistamine PRN
Local- Vinegar soaks
Wide- Cipro
Pseudomonas Cellulitis is usually found in ? PTs
These types of growth are encouraged by presence of ?
How are these PTs Tx
Debilitate/DM PTs as secondary infection of tinea
Occlusion
Broad spectrum suppression
Acetic Acid
Aluminum acetate
PO Cipro
Where do Pseudomonas Toe web infections usually present?
How does it present on PE
How are Pseudomonas toe web infections Tx
Between 4-5th toe as secondary infection after tinea
Thick white macerated skin, w/ green glow on Woods
Post-op shoe (DM PT)
Acetic acid/Aluminum chloride
Gentamycin cream once dry
PO Cipro- topical Tx failure
What causes Trichomycosis Axillaris
This infection is associated w/ ? and produces ?
Corynebacterium, Gram + opportunistic infection
Heavy sweating, malordorous smell w/ white hair
How is Trichomycosis Axillaris Tx
What microbe causes Erythrasma
Shave area
Topical Erythro, Clinda Naftifine- fungal infection
Coryn minutissiumum
What are the predisposing RFs for Erythrasma?
APHID HO Advanced age Poor hygiene Humid/warm ImmSupp DM
Hyperhidrosis
Obese
? is the MC site for Erythrasma infections to appear
How does Erythrasma appear on PE
What color is it under Woods Lamp
4th interdigital space
Macular brown itching scales
Looks like T cruris, does NOT spare scrotum/labia
Coral red
How is Erythrasma Tx
Define Pitted Keratolysis
What are the distinctive features found on PE
Erythromycin
Clindamycin
Clarithromycin- severe or refractory
Pits on weight bearing areas of feet from Kytococcus sedentarius
Malodor
Slimy/hyper hydrosis skin
How is Pitted Keratolysis Tx
What med is added if case is unresponsive to topical Txs?
TxOC: Topical E/C-mycin, Mupirocin w/ Drysol
PO Erythromycin
Define Wart
What process causes these growths
Typically these are confined to ? and lack ?
Beningn epidermal neoplasm from HPV
HPV infection of keratinocytes induces hyperplasia/keratinosis
Epidermis, no roots
How would warts be described in PE
What causes the black dots mislabeled as ‘roots’?
Verrucous papule w/ cylinders that fuse= Dx mosaic pattern
Thrombosed vessels trapped in projections
Common Wart is called ? and are MC located ?
How are they Tx
Verruca Vulgaris
Hands
Salycylic acid
Imiquimod 5%
Cantharidin (by provider)
LN2
Define Filiform Warts and where are the MC found
How are they Tx
Flat warts are AKA ? and commonly found ?
Finger-like projection
Face
Curettage- TxOC
Verruca Plana on shaved areas of body
How are Verruca Plana warts Tx
How are Plantar Warts differentiated from clavi?
How are Plantar Warts Tx
Tretinoin cream
Imiquimod
Cryosurgery
5-FU
Llook for black dots/lack of skin lines (corns have skin lines)
Cantharidin LN2 Imiquimod
Pare/soak Salicyclic acid
Define Sub/Periungual wart
Since these types are more resistant to Tx, what can be done?
Painful wart next to nail from cuticle biting
Cryosurgery
Cantharidin
Salicyclic acid
Duct tape- last option (6d, 12hr break, 6 more days)
Genital warts are AKA and cause by ?
What preventative measure slows but does NOT prevent spread
How do genital warts appear in clinic?
Condyloma acuminata
Veneral warts
HPV 6 11 16 18 52 56
Condoms
Smooth pink w/ projections on broad base
ImmSupp PTs can present w/ ? alternative presentation?
? forms of HPV are the high risk/cervical sup-types
? forms are rarely associated w/ cervical Ca
Coalesce into large cauliflower masses
16*, 18
6, 11
How are genital warts Tx by providers/
How are they Tx by PT Tx methods
Podophylin resin Excision/curettage Trichloroacetic acid Cryosurgery CO2 laser
Podofilox- 4d on, 4-6wks off
Imiquimod- every other day at bed time x 16wks
5-FU- LAST option
? two genital wart DDxs may be seen in 10% of normal male PTs
Pearly Penile Papules- angiofibromas on corona
Bowenoid- resemble flat genital warts
Sex transmitted HPV, quasi-premalignant, self resolve
Where is Molluscum Contagiosum commonly seen?
If found ?, suspect abuse
How does it present on PE
Kids via autoinnoculation on arms/face
Groin
Dome shaped papules w/ central umbilication, leak caseous material
What is the etiology of Molluscum Contagiosum
How are PTs w/ few lesions Tx
How are PTs w/ multiple lesions Tx
DNA Poxvirus
Curette w/ anesthesia- best
LN2
Trichloroacetic acid peel
? is the primary mode of herpes virus transmission
First outbreak usually appears ?days after innoculation and lasts ?
Viral cultures can occur for __ days when PTs present w/ active genital lesions
ASx viral shedding x 16 days after outbreak
6d, x 14days
5 days
? is the Gold Standard for Dx of herpes simplex
Why is this same day turn around so important
? form of HSV commonly has Abs found in PTs
PCR
Differentiates HSV 1 from 2
HSV-1
How are HSV and zoster PTs managed?
What PT education must go w/ this Rx
? medication is added to anti-viral therapy for herpes labialis
F/A/V-clovir <72hrs of onset
Improves/Shortens Sxs, but not curative
Penciclovir
Docosonal
Herpes zoster is reactivated ? and presents uniquely as ?
When is an emergent referral needed?
What vaccines are used for Herpes Zoster prevention
Varicella from dorsal root
Single dermatome
Ophthalamic branch of trigeminal d/t corneal blindness risk
Zostavax- live vaccine
Shingrix- recombinent vaccine
50 or older
Define Dermatophytes
Where is their existence limited to on the body?
What are the 3 genera of ringworms?
Fungi infecting stratum corneum (keratin layer), hair and nails
Can’t survive on mucosal layers
Microsporum Epidermophyton
Trichophyton
? mycoses infection have minimal, if any, inflammations
? infections commonly have inflammatory responses?
T versicolor (pityriasis)
T nigra
B/W piedra
T capitus (head) T barbae (beard) T faciei (face) T corporis (body ring worm) T cruris (groin, jock itch) T manuum (hand) T pedis (foot)
? is the MC mycoses infection of the skin?
Onchomycosis is AKA ?
T rubrum
Unguium, nails
What is the mode of transmission of dermatophytes?
How are these infections Dx
Human to human
Animal to human
Soil to human
Fomites
KOH Prep
DTM culture (red= +)
Woods lamp
Typically dermatophytes don’t have fluorescence response under Woods Lamp except for ?
How are superficial lesions from T Corporis Tx
How long are PTs to continue Tx?
T versicolor
Clotrim/Micon/Ketocon-azole
Continue x 7d after erythema resolves
What meds are used for T corporis if case is extensive/deep?
What med is reserved for Peds Tx?
Terbinafine
Itraconazole
Fluconazole
Griseofulvin
How are cases of T pedis Tx if interdigit presentation?
How is it Tx for moccasin presentations?
Topical: Terbinafine Clotrimazole
PO: Fluconazole Itraconazole
Terbinafine