EMED Flashcards
__ is the leading cause of death among US adults
___ causes this leading cause w/ ? predominant Sx
Ischemic heart dz
Coronary artery dz
Chest pain
High likelihood of short term risk of death in PTs w/ unstable angina
SHIPMATES BS S3 HOTN Inc TnT Prolonged MR Accelerating Sx frequency Tachy/brady Edema, pulmonary ST >0.5mm
BBB
Sustained V-tach
Low likelihood of short term risk of death from PTs w/ unstable angina?
Left coronary artery divides into ? and ? to supply ?
Reproducible w/ palpation
New/inc angina
Stable EKG
LCX and LAD
LAD: main anterior/septal
LCX: some anterior/lateral
ACS may be caused by secondary reduction of blood flow due to ?
Atherosclerotic plaques develop because of ?
Disruption/erosion of plaques
Platelet aggregation at lesions
Coronary artery spasm
Microvascular dysfunction
Repetitive wall injury
What is the classic location for MI myocardial ischemia pain?
Angina pain can be precipitated by ? events and lasts ?
Substernal/L chest radiating to arm, neck, jaw
Stress Exercise Cold
<5min w/ rest/nitro
Acute myocardial ischemia usually presents w/ more prominent pain and Sxs including ?
? PTs are more likely to have atypical presentation of MI?
Diaphoresis Nausea SoB
w/ little response to Nitro
Female
Advanced age
DM
What are the traditional RFs for ACS/AMI?
These RFs are not useful in ? PT populations
DM Tobacco FamHx
Hypercholesterolemia
HTN
ED PTs >40y/o
? PE finding may be heard indicating a failing myocardium
The presence of a new ? is ominous and may indicated ?
S3- volume overload
New systolic murmur-
Papillary dysfunction
MV leaflet flail w/ MR
VSD
S3 heart sounds are heard normally during ? and can indicate ? failure
Presence of ? on PE is indicative of LV dysfunction and L-sdied HF
Early diastole
Systolic HF
Rales, S3 regardless
Define TIMI Score
What are the parts of it
Thrombosis in MI for unstable angina
Age: >65 Markers elevated ECG depressions RFs, 3 or more Ischemic chest pain, 2 or more Coronary stenosis >50% ASA use <7days Max- 7pts
What is the single best test to identify PTs w/ AMI in the ED
This test must be obtained and interpreted w/in ?min of presentation to ED
12 lead EKG
<10min
What is the ‘general’ definition of an STEMI
ST elevation suggests ? while depression suggests ?
ST elevation of 1mm or more in two contiguous leads w/ reciprocal changes
Ele: transmural injury/infarction
Dep: ischemia
What is the next step for suspected inferior wall AMI?
What finding is Dx
R sided EKG
ST elevation in V4R= RV infarction
PTs w/ RV infarction are ? dependent, be careful if using ?
Pts w/ non-Dx EKG but persistent Sxs have ? follow on test?
Pre-load dependent
Nitro/BBs
Repeat EKG
If reciprocal EKG changes are seen, ? does this indicate?
How does the height of ST elevations correlate to severity?
Larger area Increased severity Severe pump failure Inc CV complications Inc mortality
High= more extensive injury
What leads are used for posterior MIs?
What artery is involved w/ this type?
V7-9
Circumflex
LBBB criteria
What is the MC pacemaker lead location?
Elevation 1mm+, concordant
Elevation 5mm+, discordant
Depression 1mm+ V1-3
RV pacing
Where is Welens seen on EKG and what does it indicate
Why is this difficult to Dx
V2-3, possibly V1-4
LAD stenosis
T-waves present during pain free period
T-waves absent during painful episode
Wellen’s PTs are likely to develop ? type of MI
When are serum biomarkers not needed for Dx
When are these markers useful?
Anterior
Dx ST segment elevations
Non-Dx EKGs of NSTEMI
Risk stratification during N/STEMI and unstable angina
How can cardiac injury be differentiated between acute or chronic?
How long does it take for troponin to rise, peak and return to normal?
Delta troponin over 1-3hrs
3-12hrs
12-24hrs
5-14days
How are STEMI PTs Tx
They usually get ? three meds in the ED?
What medication is added to unstable angina, refractory NSTEMI or pre-PCI?
PCI w/in 90-120min
Fibrinolysis <30min of arrival
Anti platelet/thrombins and Nitrates
G-2b/3a antagonist
What are the 4 anti-platelet meds used during the Tx of STEMI?
What 3 anti-thrombins are used?
Clopidogrel ASA Prasugrel
Ticagrelor
UFH Enoxaparin Fondaparinux
What are the 5 fibrinolytic agents used?
What are the names of the G2a/3b meds?
What are the 4 additional anti-ischemic meds may be used?
Streptokinase
TARA-plase
Abciximab Tirofiban Eptifibatide
Nitro Morphine Metoprolol Atenolol
The invasive Tx approach seen in STEMI Tx is only applied to NSTEMI PTs if ?
If unstable angina/NSTEMI are hemodynamically unstable, start invasive Tx strategies w/in ? time fram
Refractory angina
Hemodynamic/electric instability
Inc risk for clinical events
PCI <2hrs
What direct thrombin inhibitor is used during unstable angina/NSTEMI not used for STEMI Tx
What anti-ischemic therapy is NOT used for NSTEMI?
Bivalirudin
Atenolol
What is the recommended method to repurfsion NSTEMIs
What is the MC type of this method?
PCI w/in 90-120min
Coronary angioplasty
What two meds may be added to PTs receiving coronary stents during PCI?
What are fibrinolytics MOA during NSTEMI Tx
Fibrinolytic therapy improves ? part of the heart in particular?
Thienopyridines
G2b/3a inhibitors
In/Direct plasminogen activators
LV function
What criteria must be met to use fibrinolytics during NSTEMI Tx
This form of reperfusion is better started early for ? MIs in ? location
<12hrs from Sx onset
ECT w/ one ST elevation >1mm in two or more leads
Larger/anterior
After a failed fibrinolytic administration, rescue PCI is recommended for ? PTs
<75y/o
Severe HF/edema
Hemodynamic compromising ventricular arrhythmias
Mod/large area of myocardium at risk
What is the most catastrophic complication of fibrinolytic therapy?
If fibrinolytics are used in STEMI PTs, how are they used?
Intracranial bleeds
Full dose UFH/Enox/Fonda x 48hrs
MOA of G2b/3a antagonists
MOA of ASA
Interrupts platelet activation
Inhibits platelet aggregation d/t thromboxane A2 stimulation mediated by arachidonic acid pathway
All unstable angina, N/STEMI PTs get ? med?
What is the alternative medication used but only if ?
325mg ASA
Clopidogrel
True allergy/active PUD
What is the ADP receptor antagonist used in ACS
This med is c/i in ? PTs
What is the benefit of using this med?
Prasurgel- irreversible
Hx of CVA/TIA/bleeding
Effect gone w/in 3 days of d/c
Why is LMWH used in NSTEMI PTs more often?
STEMI PTs Tx w/ ASA and ? had better outcomes
Greater BioAvail
Lower protein binding
Longer t1/2
More reliable anticoag effect
Enoxaparin
Nitro provides ? benefits to ACS PTs
When Nitro is used in AMI PTs not Tx w/ thrombolytics, what are the 3 benefits?
Relaxes smooth muscles/dilation
Inhibits platelet aggregation
Reduces infarct size
Improves regional function
Dec rate of CV complications
If nitro is used in AMI PTs, titrate to ? not ?
Recommend using IV Nitro for first 24-48hrs for ? PTs
BP, not Sx resolution
STEMi and recurrent ischemia
CHF
HOTN
Don’t use Nitro in PTs that have taken which phosphodiesterase inhibitors w/in ?hrs
Start PO BBs in N/STEMI Pts w/in 24hrs as long as they don’t have ?
Sildenafil- 24hrs
Tadalafil- 48hrs
S/Sxs of HF
Low CO
Risk for cardiogenic shock
What are the relative c/is to giving BBs?
What are the c/is to giving ACEIs within 24hrs
2/3* block
PR interval >0.24 sec
Asthma
Reactive airway dz
HOTN Bilateral renal stenosis RF Hx of cough Angioedema w/ past ACEI use
Of all the meds, what ones may be used during ACS that don’t improve mortality?
When would they be used?
CCBs
Verapamil/Diltiazem if: Ongoing ischemia A-fib w/out CHF LV dysfunction AV blocks Absolute c/i to BBs
Anterior wall AMIs typically cause PTs to acquire ? dysrhythmia?
Why is this finding ominous?
Sinus tachy
Persistent sinus tachy= poor prognosis
PTs w/ SCT, Afib/flutter post MI are best Tx w/ ?
What type of acquired rhythm is not associated w/ an increased mortality
Direct current cardioversion
Sinus brady w/out HOTN
? med is used for sinus brady causing HOTN, ischemia, ventricular escape rhthyms or Sx AV blocks?
Anterior/inferior MIs can cause PTs to develop ?
Atropine
Complete heart blocks
? type of rhythms are usually transient and seen w/in 48hrs of an infarct?
Ventricular premature contractions are more common in PTs w/ ? and are ?
Junctional rhythms
AMI
Benign
New RBBB can occur MC in ? AMI
Previously stable PT that suddenly decompensates needs to have ? Dx r/o
Anteroseptal
Mechanical complication
? post-AMI complication can occur 1-5 days after and lead to tamponade/death
How does it present?
Ventricular wall rupture
HOTN/Tachy
JVD
Dec sounds
Pulsus paradoxus
What is the DxTOC for ventricular free wall ruptures?
How is a ruptured septum detected, Dx and Tx
Echo w/ surgical Tx
New holo murmur
Pain/dyspnea
Doppler echo, surgery
Rupture of the interventricular septum is more common after ? type of AMI
Papillary muscle ruptures are more common w/ ? type of MI and present w/ ?
Anterior wall
Extensive/three vessel CADz
Inferior wall
Day 3-5 post-MI
Dyspnea, HF
New holo murmur w/ MR
PTs are more likely to develop pericarditis after ? type of MI
These PTs are more likely to develop ? than actual pericarditis
Transmural and delayed presentation
Pericardial effusion
How is post-MI pericarditis or Dresslers Tx
If PT develops Dresslers 2-10wks later, how do they present?
ASA or Colchicine
No Ibuprofen- interferes w/ ASA anti-platelet effect
Pain Fever Pleuropericarditis
? PT presentation suggests a possible inferior wall MI is present
How are these Dx
JVD/HOTN after giving Nitro
Echo/Nuclear imaging
What is the most serious complication that can occur from a RV infarct?
How are these types Tx
Shock
Maintain preload (NS)
Reduce RV after load
Inotropic support
Early repurfusion
Post-PCI PT presenting w/ chest pain has ? Dx until proven other wise
What is the more likely and less likely cause for their presentation?
Abrupt vessel closure
Bare metal- more likely to re-stenose
Drug eluding- late stent thrombosis 9-12mon later after d/c Clopidogrel
What is the most sensitivity biomarker for cocaine induced MI?
What three drugs are used as mainstay Tx
? are c/i for the first 24hrs
Cardiac troponin
Benzo ASA Nitrate
BBs
Define HF
What are the cardinal manifestations of HF
Impaired ventricular filling or ejection of blood
Peripheral edema
Dyspnea and fatigue
Fluid retention
What is the counter regulatory response to HF
What are the 3 types of this response?
Natriuretic peptides
A- atrial
B: ventricle
C: endothelium
What two effects do natriuretic peptides produce?
PTs w/ acute HF and pulmonary edema may benefit from ? Tx to prevent intubation
Vasodilation
RAAS/SNS inhibition
BiPap
What are the 6 phenotypes of acute HF?
HTN HF: SBP >140
Pulm Edema: distress, rales
Cardiogenic shock: SBP <90, hypoperfusion
Acute on Chronic: S/Sxs of AHF but BP <140 and >90
High Output: tachy, warm, congested
Right HF: low output w/ JVD, megaly and HOTN
How do PTs w/ acute on chronic HF present
High output HF is distinguished by a normal ? and often caused by ?
Gradual Sxs and weight gain from days/wks
Normal EF
Anemia/Thyrotoxicosis
Define Systolic Dysfunction HF
Define Diastolic Dysfunction HF
This may be an early initiator of ? cascade
HF w/ reduced EF <50%
Impaired ventricle emptying
HF w/ preserved EF
Impaired ventricular relaxation (chronic HTN)
Ischemic
How is HF Dx
What is the most useful parameter for Dx?
Clinically w/ Hx and PE
Hx of HF
What are the RFs for HF
What Sx has the highest sensitivity for Dx?
What are the 3 most specific Sxs?
DM Obese Valve dz
HTN Age Male
Dyspnea
Paroxysmal nocturnal dyspnea
Orthopnea
Edema
On PE, what finding has the highest likelihood ratio for acute HF?
What are the only other two findings that have a high likelihood ratio over 5?
S3
Abdominojugular reflux
JVD
What component of a HF workup out performs all Dx tests available?
What lab result has the most similar accuracy?
Clinical gestalt
BNP
What CXR findings are most specific for a final Dx of acute HF?
What EKG finding has the highest likelihood ratio for Dx HF?
Venous congestion
Interstitial edema
Cardiomegaly
Afib
What 3 factors can affect biomarker levels?
Bedside cardiopulmonary US can be used to address ? 3 questions?
Mass Age Gender
Signs of pulm congestion
Sign of volume overload
Low/norm LV EF
Pulmonary US is first used to determine if pulmonary congestion is present by looking for ?
These findings are sonographic equivalent to ? on CXR
B-lines
Kerley-B linesW
What pulmonary US finding is pathologic and highly specific for alveolar/interstitial edema?
Because these findings can be found in numerous other conditions, what f/u test is needed
More than two b-lines on any sonographic window
Elevated central venous pressure as marker for R hear congestion
IVC >2cm/collapse index <50% indicates elevated pressure
What step is the final piece of the ED based bedside US?
What is the initial approach to HF Tx
LV EF
Airway w/ goal of >95%
Acute HF w/ HOTN is Tx w/ ? meds
How are PTs w/ acute HF and HTN Tx and what is added if further load reduction is needed?
Dobutamine NorEpi Dopamine
Nitro
IV Nitroprusside after >200mcg of Nitro
When Tx HTN acute HF, always start ? med prior to using ?
How are normotensive HF PTs Tx
Nitrates before diuretics (Furosemide)
Loop diuretics 40mg IV
What adverse outcome can occur when treating normotensive HF?
Ongoing congestion/dyspnea after administering loop diuretics indicates need for ?
HypoK/Ca/Mg
Ototoxicity, especially if using aminoglycoside ABX
Vasodilators
What medication can be used for congestion and anxiety while Tx normotensive HF?
If diuretic and medical strategies fail, what procedure is used and especially good for lowering water/Na?
Morphine
Ultrafiltration
What med is used for normotensive HF Tx when Nitro is ineffective or c/i
Nesiritide- recombinant human BNP
How to dose Furosemide
What are 5 high risk markers in ED PTs w/ HF associated w/ morbidity/mortality?
No Hx of use: 20-40mg IVP
Hx of use: total daily dose x 1-2.5, divide in half and give IV bolus q12hrs
Renal dysfunction
Low BP/Na
Elevated BNP/troponin
Define Primary Cardiomyopathies
Define Secondary Cardiomyopathies
As a group these make the the third MC form of ?
Dz involving myocardium
Heart dz w/ systemic d/os
Cardiac dz in US after coronary/ischemic and HTN heart dz
What is the second MC cause of sudden cardiac death in adolescents?
? is the MC form of cardiomyopathy
Hypertrophic cardiomyopathy
Dilated
Peripartum cardiomyopathy manifests as ?
What is the primary indication for heart transplants in the US?
Dilated cardiomyopathy
Idiopathic dilated cardiomyopathy