Precocious_Puberty_Flashcards COPY
1
Q
What is Gonadotrophin-Dependent Precocious Puberty?
A
90% in females has NO identifiable cause. Managed by addressing associated brain neoplasms and using GnRH agonist (e.g., leuprolide) to suppress puberty via negative feedback. GH therapy may be used as GnRH agonists can stunt growth. Cryproterone (anti-androgen) is used by specialists.
2
Q
How is Gonadotrophin-Independent Precocious Puberty managed?
A
Different causes require specific treatments: McCune Albright or Testotoxicosis: ketoconazole or cyproterone, GnRH agonist, aromatase inhibitors. Congenital Adrenal Hyperplasia: adjustment of hydrocortisone therapy, GnRH agonist. Tumours: specialist referral.
