Haemophilia_Flashcards

Question 1

What is the recommended treatment for Haemophilia A?

Answer 1

Recombinant factor VIII concentrate is the recommended treatment for Haemophilia A.

Question 2

What is the recommended treatment for Haemophilia B?

Answer 2

Recombinant factor IX concentrate is the recommended treatment for Haemophilia B.

Question 3

How are acute bleeds in haemophilia managed?

Answer 3

Acute bleeds in haemophilia are treated with factor concentrates and anti-fibrinolytics (e.g. aminocaproic acid, tranexamic acid). These should be given by prompt IV infusion whenever there is any bleeding.

Question 4

What should be avoided in patients with haemophilia?

Answer 4

In patients with haemophilia, the following should be avoided: IM injections, aspirin, and NSAIDs.

Question 5

What is a potential complication of factor VIII treatment in Haemophilia A?

Answer 5

10-15% of patients with Haemophilia A will develop antibodies to factor VIII treatment.

Question 6

What additional care might be required for deep bleeds into muscles and joints in haemophilia patients?

Answer 6

Analgesia, physiotherapy, orthopaedic, and pain team review may be required for deep bleeds into muscles and joints in haemophilia patients.

Question 7

What is the purpose of prophylactic factor VIII in children with severe Haemophilia A?

Answer 7

Prophylactic factor VIII is given to all children with severe Haemophilia A to further reduce the risk of chronic joint damage.

Question 8

How can mild Haemophilia A be managed to stimulate the release of factor VIII and vWF?

Answer 8

Desmopressin (DDAVP) may be useful in mild Haemophilia A as it stimulates the endogenous release of factor VIII and vWF.