ITP_Flashcards
What is the typical course of Immune Thrombocytopaenic Purpura (ITP) in children?
In 80% of children, ITP is acute, benign, and self-limiting.
How long does it typically take for ITP to resolve spontaneously in children?
ITP will resolve spontaneously within 6-8 weeks.
Where are most children with ITP managed?
Most children with ITP can be managed at home.
When is treatment indicated for children with ITP?
Treatment is indicated for ITP if there is evidence of major bleeding (e.g., intracranial or gastrointestinal) or persistent minor bleeding that affects daily life (e.g., excessive epistaxis).
What is the management for life- or organ-threatening bleeding in ITP?
Management for life- or organ-threatening bleeding in ITP includes IVIG, corticosteroid, platelet transfusion, and possibly antifibrinolytics (aminocaproic and tranexamic acid).
What is the management for a newly diagnosed child with ITP who is asymptomatic or has minor bleeding?
Management for a newly diagnosed child with ITP who is asymptomatic or has minor bleeding involves observation, as most will achieve a normal platelet count eventually.
What is the management for a newly diagnosed child with ITP who has major bleeding?
Management for a newly diagnosed child with ITP who has major bleeding includes corticosteroids, IVIG or anti-D immunoglobulin.
What treatments are considered for children with chronic ITP?
Treatments for children with chronic ITP include mycophenolate mofetil, rituximab, eltrombopag (thrombopoietin receptor agonist), and as a 2nd line, splenectomy if the condition is persistent.
