Bio Ch 9 Flashcards
Interphase
majority of the cell cycle
Cell cycle
orderly set of stages that take place between the time a eukaryotic cell divides and the time the resulting daughter cells also divide
Chromatid
double helix of DNA
Sister chromatids
2 identical chromatids
Mitosis
nuclear division
Cytokinesis
division of the cytoplasm
Mitotic spindle
during mitosis, daughter chromosomes are distributed by this to 2 daughter nuclei
Signal
agent that influences the activities of a cell
Growth factors
signaling proteins received at the plasma membrane
Cyclins
family of internal signaling proteins; increase and decrease as the cell cycle continues
p53
signaling protein in mammalian cells that stops the cycle at the G1 checkpoint when DNA is damaged (# = molecular weight in kilodaltons)
Apoptosis
programmed cell death
RB
protein responsible for interpreting growth signals and also nutrient availability signals; retinoblastoma, a cancer of the retina that occurs when this gene undergoes a mutation
Caspases
enzymes that bring about apoptosis
Somatic cells
body cells
Histones
proteins that are especially involved in organizing chromosomes
Chromatin
when a eukaryotic cell is not undergoing division, the DNA and associated proteins are located within this, which has the appearance of a tangled mass of thin threads
Diploid (2N) number
full number of chromosomes that is found in all cells of the individual; 2 chromosomes of each kind
Haploid (n) number
half the diploid number; contains only 1 chromosome of each kind; only sperm and eggs have this number of chromosomes in the life cycle of animals
Centromere
sister chromatids are constricted and attached to each other at this region
Kinetochores
protein complexes that develop on either side of the centromere during cell division
Centrosome
main microtubule organizing center of the cell; divides before mitosis begins
Centrioles
barrel-shaped organelles; pair in each centrosome in an animal cell; not found in plant cells
Prophase
nuclear division is about to occur; chromatin has condensed and the chromosomes are visible; nucleolus disappears and the nuclear envelope fragments; spindle begins to assemble as 2 centrosomes migrate away from one another
Asters
array of microtubules radiates toward the plasma membrane from the centrosome; serve to brace the centrioles during later stages of cell division
Prometaphase
preparations for sister chromatid separation are evident; kinetochores appear on each side of the centromere (attach sister chromatids to the kinetochore spindle fibers)
Metaphase
centromeres of chromosomes are in alignment on a single plane at the center of the cell
Metaphase plate
an imaginary plane that is perpendicular and passes through the circle in the center of the cell; indicates the future axis of cell division
Anaphase
2 sister chromatids of each duplicated chromosome separate at the centromere, giving rise to 2 daughter chromosomes; shortest phase of mitosis
Telophase
the spindle disappears as new nuclear envelopes form around the daughter chromosomes
Cleavage furrow
indentation of the membrane between 2 daughter nuclei, forms as anaphase draws to a close
Cell plate
newly formed plasma membrane that expands outward until it reaches the old plasma membrane and fuses with it; in plant cells
Therapeutic cloning
used to produce human tissues; can begin with adult stem cells or embryonic stem cells
Reproductive cloning
production of a new individual
Cancer
cellular growth disorder that occurs when cells divide uncontrollably
Benign
not cancerous
Malignant
cancerous & possesses the ability to spread
Tumor
abnormal cancer cells pile on top of one another and grow in multiple layers; most aggressive cell becomes the dominant cell of this
Metastasis
spread of cancer from the place of origin throughout the body; caused by the ability of cancer cells to migrate and invade tissues
Angiogenesis
additional mutations occur in tumor cells, allowing them to direct the growth of new blood vessels into the tumor
Proto-oncogenes
code for proteins that promote the cell cycle and prevent apoptosis; likened to the gas pedal of a car because they cause the cell cycle to speed up
Tumor suppressor genes
code for proteins that inhibit the cell cycle and promote apoptosis; often linked to the brakes of a car because they cause the cell cycle to go more slowly or even stop
Oncogenes
Cancer-causing genes
Telomeres
ends of chromosomes
Asexual reproduction
offspring are genetically identical to the parent
Nucleoid
electron-dense, irregularly shaped region of bacterial chromosomes; not enclosed by a membrane
Binary fission
asexual reproductive process of prokaryotes; division (fission) produces 2 (binary) daughter cells that are identical to the original parent cell