TERMS

Question 1

what is this anti fungal?

inhibition of cyp450 12 alpha demethylase which inhibits conversion of lanosterol into ergosterol

Answer 1

azoles

-zole

Question 2

what is this antifungal?

inhibits beta 1,3-D-glucan synthase leading to disruption of cell wall integrity and then death

Answer 2

echinocandins

-fungin

Question 3

what is this anti fungal?

binds to ergosterol in the fungal membrane leading to pores made in the membrane then to leakage of cell contents and then death

Answer 3

polyene

-amphotericin

Question 4

this amphotericin drug?

gets converted to 5-fluorouracil in the fungal cell leading to further conversion to metabolite that interferes with protein/DNA synthesis

Answer 4

flucytosine

Question 5

name this topical azole?

onychomycosis(trichophytan rubrum/mentagorphytes)

Answer 5

efinaconazole

Question 6

name this topical azole?

lozenge (oropharyngeal candidiasis/thrush)
cream (vulvovaginal candidiasis and all tinea)

Answer 6

clotrimazole

Question 7

name this topical azole?

tablet (thrush)
cream (vulvovaginal candidiasis)
cream/ointment/aerosol/e tab

Answer 7

miconazole

Question 8

name this topical azole?

cream/foam/gel/shampoo (cutaneous candidiasis, dandruff, seborrheic dermatitis, tinea)

Answer 8

ketoconazole

Question 9

Misc anti fungal?

Mechanism – inhibits squalene epoxidase, a key enzyme in ergosterol synthesis → cell death

▪ Clinical uses – tinea, onychomycosis

Answer 9

Terbinafine

Question 10

Misc anti fungal?

Mechanism – inhibits fungal cell mitosis at metaphase; binds to human keratin making it resistant to fungal invasion
• Fungistatic

Clinical uses – tinea and onychomycosis

Answer 10

Griseofulvin (oral only)

Question 11

Misc anti fungal?

Mechanism – inhibits transport of essential elements (especially trivalent metal cations) of the fungal cell
• Disrupts the synthesis of DNA, RNA and protein

▪ Clinical Uses – Tinea, cutaneous candidiasis, seborrheic dermatitis, onychomycosis

Answer 11

Ciclopirox