LAST MINUTE MISC SYM AGONISTS

Question 1

a1 selective agonist as direct acting sympathomimetic

orthostatic hypotension

Answer 1

midodrine

Question 2

alpha and beta receptors causing NE release from tissue stores

hypotension during anesthesia

OTC: weight loss products (PO)

OTC: asthma symptoms (PO)

Answer 2

ephedrine

Question 3

enantiomer of ephedrine

agonist of alpha and beta adrenergic receptors for nasal decongestant, in many OTC products

CNS stimulation, nervousness

Answer 3

pseudoephedrine

Question 4

indirect acting alpha and beta actions stimulating release of DA and NE blocking reuptake

used in treatment of ADHD

similar to methamphetamine

Answer 4

amphetamine

Question 5

indirect, inactivated by monoamine oxidase in the liver (high first pass)

drugs that inhibit MAO may increase tyramine levels significantly increasing catecholamines for hypertension

Answer 5

tyramine

Question 6

this drug inhibits reuptake of NE into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals

Answer 6

reserpine

Question 7

nonselective alpha 1, alpha 2 receptor antagonists decreasing peripheral resistance

treatment for pheochromocytoma?

Answer 7

phentolamine or phenoxybenzamine

Question 8

alpha 1 antagonist selective

treatment for hypertension and BPH

Answer 8

prazosin
terazosin
doxazosin

Question 9

alpha 1 antagonist selective

treatment for BPH only

Answer 9

alfuzosin
tamsulosin
silodosin

Question 10

alpha 2 adrenergic agonist promoting vasoconstriction used for HTN, withdrawal, migraine

Answer 10

clonidine

Question 11

apraclonidine and brimonidine are derivative used as _____

a2 adrenergic agonist, treats glaucoma, crosses the BBB (brimonidine), apraclonidine does not

Answer 11

eye drops