BETA LACTAMS II

Question 1

occasional adverse drug reactions?

Answer 1

hypersensitivity
GI intolerance
Drug fever
Coombs test positive
phlebitis

Question 2

rare adverse drug reactions?

Answer 2

anaphylaxis
hemolytic anemia
thrombocytopenia

Question 3

what are the major penicillin/beta lactase inhibitor combos?

Answer 3

ampicillin with:

sulbactam
clavulanate
tazobactam

Question 4

beta lactamase inhibitors protect antibiotics from?

what does this not enhance?

Answer 4

beta lactamase which broaden antimicrobial spectrum

intrinsic activity

Question 5

this penicillin/beta lactase inhibitor combo is IV only for moderate to severe infections

SSTI, diabetic foot ulcers, aspiration pneumonia, gynecological infections, actinobacter baumanii

Answer 5

ampicillin/sulbactam

Question 6

this penicillin/beta lactase inhibitor combo is PO-mild to moderate infections

respiratory infections, UTIs, otitis media, pharyngitis, community acquired pneumonia, tonsillitis

Answer 6

amoxicillin/clavulnate

Question 7

this is the good spectrum for what penicillins?

MSSA
streptococci
enterococci
many anerobes
enteric GNRs
H influenzae

Answer 7

penicillin/beta lactamase inhibitor combos

Question 8

these penicillins are very broad spectrum, what are they?

widely distributed into tissues and body fluids

30% hepatic ally metabolized and really eliminated

IV route leads to serious infections

Answer 8

antipseudomonal penicillins

Question 9

this is the only carboxypenicillin available in the US and its as a beta lactamase inhibitor and leads to increased stability of piperacillin against class A beta lactamases?

Answer 9

piperacillin-tazobactam

Question 10

this penicillin has the following good spectrum against:

MSSA
streptococci
enterococci
anaerobes
enteric GNRs
pseudomonas

Answer 10

antipseudomonal penicillins