TERMS

Question 1

nucleoside analogs that after phosphorylation are incorporated into the elongating DNA strand just like cellular nucleotides

Answer 1

HSV/VZV drugs

• acyclovir
• valacyclovir
• famiciclovir

Question 2

MOA for this anti CMV drug?

nucleoside analogue that integrates into viral DNA by DNApol, stopping viral replication?

prodrug of ganciclovir?

similar to ganciclovir?

pyrophosphate analogue acting as a noncompetitive inhibitor of many viral RNA/DNApols

Answer 2

ganciclovir

valganciclovir

cidofovir

foscarnet

Question 3

MOA for this anti influenza drug?

competitive inhibitors of viral neuraminidase, an enzyme responsible for several functions of influenza virus, including the release of new virions from infected cells (NA inhibitor??

Answer 3

oseltamivir
zanamivir
peramivir

Question 4

name this class of antiretrovirals?

competitive analogues of naive nucleotides to inhibit replication

act as chain terminator to inhibit reverse transcription of viral RNA genome into DNA

Answer 4

NRTIs

-VIR ending

Question 5

name this class of antiretrovirals?

binds to RT via noncompetitive inhibition away from active site inducing conformational change leading to reduced enzyme function

binding site for NNRTIs is virus strain specific with no activity against host cell DNA polymerase

Answer 5

NNRTIs

Question 6

name this class of antiretrovirals?

inhibits HIV protease which is responsible for cleaving immature budding particles leading to prevent processing of viral proteins into functional components

Answer 6

protease inhibitors

-avir

Question 7

name this class of antiretrovirals?

inhibits the catalytic enzyme, integrates, from incorporating the HIV genetic code into the hosts genome

Answer 7

integrase inhibitors
(INSTIs)

Question 8

name this class of antiretrovirals?

binds to CCR5, changes confirmation, prevents HIV from binding gp120-CCR5 receptor on the host cell

3A4 substrate with many interactions

Answer 8

entry inhibitor

-maravirac

Question 9

name this class of antiretrovirals?

binds to gp41, blocking the conformational change needed to fuse the two membranes

• SQ injection
• reserved for difficult to treat, resistant strains

Answer 9

fusion inhibitor

-enfuvirtide

Question 10

drug used with the following MOA for viral hepatitis?

inhibits DNA and RNA viruses

Answer 10

ribavirin