DRUGS USED IN COAGULATION PROCESS

Question 1

what are the anticoagulants?

Answer 1

unfractionated heparin
low molecular weight heparin
warfarin
diret thrombin inhibitors
factor Xa ihibitors

Question 2

MOA is for this drug:

stimulates antithrombin III

Answer 2

heparin

Question 3

MOA for this drug:

stimulates antithrombin III
more specific to factor Xa (more predictable than heparin)
renally eliminated

Answer 3

low molecular weight heparin (LMWH)

Question 4

MOA for this drug:

interferes with hepatic synthesis of vitamin K dependent coagulation factors, which are also?

impairs fxn of these proteins (2 of them) which are natural coagulants?

Answer 4

warfarin

Question 5

this drug is used as an anticoagulant for patients with heparin induced thrombocytopenia (HIT)

adjunctive therapy in patients undergoing percutaneous coronary intervention

Answer 5

thrombin inhibitors

Question 6

this drug is an oral factor IIa (thrombin) inhibitor

Answer 6

dabigatran etexilate

Question 7

this drug used as a prophylaxis of DVT, and for treatment of DVT and PE

Answer 7

fondaprinux, factor Xa inhibitor

Question 8

this drug is a synthetic oral direct factor Xa inhibitor, inhibits free and clot bound factor Xa activity

Answer 8

rivaroxaban, factor Xa inhibitor

Question 9

oral direct factor Xa inhibitor drug
inhibits free Xa and prothrombinase activity
bioavailability is 50% with or without food
25% renally excreted

Answer 9

apixaban, factor Xa inhibitor

Question 10

this thrombolytic drug is a recombinant tissue plasminogen activator that activates plasminogen bound to fibrin

MOA is conversion of plasminogen to plasmin

Answer 10

alteplase

Question 11

this thrombolytic drug is synthesized by streptococci and combines with pro activator plasminogen

MOA is conversion of plasminogen to plasmin

Answer 11

streptokinase

Question 12

this hemostatic agent inhibits plasminogen activity and may reverse the effects of thrombolytics

Answer 12

aminocaproic acid and aprotinin

Question 13

this is a drug used as a reversal agent for apixaban or rivaroxaban causing an uncontrolled bleed

Answer 13

adenxanet alpha

Question 14

humanized monoclonal (Fab) binds to dabigatran and metabolites

binding affinity is 350x greater than thrombin with effect in minutes

duration around 24 hrs

short half life dabigatrin and so treatment warrants immediate discontinuation

Answer 14

dabigatran