CEPAHLOSPORINS

Question 1

what gen has poor CNS penetration?

Answer 1

first

2nd

Question 2

poor spectrum for all the gens?

Answer 2

listeria
atypicals
MRSA
enterococcus
Pseudomonas

Question 3

this second generation drug used may cause prolonged bleeding and if taken with alcohol can cause a disulfiram like reaction?

Answer 3

cefotetan

Question 4

this gen is broad spectrum and ineffective against ESBL producing bacteria

Answer 4

3rd gen

Question 5

this 3rd gen drug is eliminated via biliary and renal; doesn’t require renal adjustment

Answer 5

ceftriaxone

Question 6

this is the only 3rd gen drug that has activity against pseudomonas aeryginosa?

Answer 6

ceftriaxone

Question 7

this gen has increased binding activity to PBP, ACTIVE AGAINST MRSA, good gram neg coverage and ineffective against ESBL

Answer 7

ceftaroline

Question 8

main difference against ceftazidime-avibactam and ceftalozane-tazobactam drugs?

Answer 8

the tazobactam has no activity against KPCs

Question 9

cephalosporins + beta lactamase inhibitor good against?

Answer 9

pseudomonas
ESBL producing gram neg pathogens
GNRs

moderate against KPC