BILE ACID SEQUESTRANTS

Question 1

examples?

Answer 1

cholestyramine
colestipol
colesevelam

Question 2

MOA?

Effectiveness?

ADRs and Precautions?

Answer 2

Binds bile acids in the intestines; inhibits enterohepatic reuptake of bile; inhibits cholesterol absorption in the intestines

LDL reduction: 12%-20%

Impairs absorption of other drugs e.g. warfarin,
phenytoin, levothyroxine, tetracyclines, folic acid,
digoxin, vitamins A, D, E, K

Question 3

BAS should be reserved only for?

Answer 3

patients unable to tolerate ezetimibe who need additional LDL-C lowering despite maximally tolerated statin therapy