PHARMACODYNAMICS HIGH YIELD Flashcards
determinants for effective pharmacology?
pharmacokinetics
this is the study of the effect of drugs on biologic systems and govern the concentration effect part of the interaction
pharmacodynamics
what the types of drugs?
xenobiotics
hormones
poisons
toxins
what are the natures of drugs?
ligands
receptor
agonist/antagonist
the interaction of drugs require?
size
electrical charge
shape
atomic composition
what is the size for the drug to achieve selective binding?
affect if the drug is larger than 1000MW?
100 MW
do not diffuse between the compartments of the body
affect of chiral molecules?
asymmetric center
enantiomers
what is the term if all enantiomers are included in the drug to be administered?
racemic mixture
what are the two types of drugs in terms of selectivity?
nonselective drugs
selective drugs
what are the types of drug receptor bonds?
covalent bonds (strong and reversible, aspirin) electrostatic bonds (weaker than covalent, more common, more selective) hydrophobic bonds (very weak bonds, highly lipid soluble, self associate in an aqueous environment)
what are the types of drug receptor interactions?
agonist
competitive inhibitor
allosteric activator
allosteric inhibitor
what type of drug receptor is buprenorphine?
partial agonist
what are the types of antagonists?
competitive
noncompetitive
allosteric antagonist
T/F, competitive antagonism is reversible?
T
name this beta blocker?
non selective beta blocker
competes with norepinephrine and epinephrine
reduces resting heart rate
exhibits competitive antagonism
propanolol
what is an example of the spare receptor, importance?
maximal inotropic response of heart muscle to catecholamines can be achieved even when 10% of Beta adrenoceptors available
T/F, a noncompetitive antagonist reduces the maximal response that an agonist can produce and that increasing the agonist concentration can’t surmount the inhibitory effect
T
name this drug and type of drug-receptor?
used to treat hypertension in patients with pheochromocytoma
alpha-adrenoceptor antagonist
effectively lowers blood pressure
be careful, patient may become hypotensive
phenoxybenzamine
what are the types of drug receptors?
regulatory protiens
enzymes
transport proteins
structural proteins
what are the two types of receptor regulation?
downregulation
upregulation
EGF receptor kinase illicits what type of receptor regulation?
down regulation
how is tachyphylaxis related to receptor regulation?
when responsiveness to a drug diminishes rapidly after administration of a drug like acute tolerance
