PHARMACODYNAMICS HIGH YIELD

Question 1

determinants for effective pharmacology?

Answer 1

pharmacokinetics

Question 2

this is the study of the effect of drugs on biologic systems and govern the concentration effect part of the interaction

Answer 2

pharmacodynamics

Question 3

what the types of drugs?

Answer 3

xenobiotics
hormones
poisons
toxins

Question 4

what are the natures of drugs?

Answer 4

ligands
receptor
agonist/antagonist

Question 5

the interaction of drugs require?

Answer 5

size
electrical charge
shape
atomic composition

Question 6

what is the size for the drug to achieve selective binding?

affect if the drug is larger than 1000MW?

Answer 6

100 MW

do not diffuse between the compartments of the body

Question 7

affect of chiral molecules?

Answer 7

asymmetric center

enantiomers

Question 8

what is the term if all enantiomers are included in the drug to be administered?

Answer 8

racemic mixture

Question 9

what are the two types of drugs in terms of selectivity?

Answer 9

nonselective drugs

selective drugs

Question 10

what are the types of drug receptor bonds?

Answer 10

covalent bonds (strong and reversible, aspirin)
electrostatic bonds (weaker than covalent, more common, more selective)
hydrophobic bonds (very weak bonds, highly lipid soluble, self associate in an aqueous environment)

Question 11

what are the types of drug receptor interactions?

Answer 11

agonist
competitive inhibitor
allosteric activator
allosteric inhibitor

Question 12

what type of drug receptor is buprenorphine?

Answer 12

partial agonist

Question 13

what are the types of antagonists?

Answer 13

competitive
noncompetitive
allosteric antagonist

Question 14

T/F, competitive antagonism is reversible?

Answer 14

T

Question 15

name this beta blocker?

non selective beta blocker
competes with norepinephrine and epinephrine
reduces resting heart rate
exhibits competitive antagonism

Answer 15

propanolol

Question 16

what is an example of the spare receptor, importance?

Answer 16

maximal inotropic response of heart muscle to catecholamines can be achieved even when 10% of Beta adrenoceptors available

Question 17

T/F, a noncompetitive antagonist reduces the maximal response that an agonist can produce and that increasing the agonist concentration can’t surmount the inhibitory effect

Answer 17

T

Question 18

name this drug and type of drug-receptor?

used to treat hypertension in patients with pheochromocytoma

alpha-adrenoceptor antagonist

effectively lowers blood pressure

be careful, patient may become hypotensive

Answer 18

phenoxybenzamine

Question 19

what are the types of drug receptors?

Answer 19

regulatory protiens
enzymes
transport proteins
structural proteins

Question 20

what are the two types of receptor regulation?

Answer 20

downregulation

upregulation

Question 21

EGF receptor kinase illicits what type of receptor regulation?

Answer 21

down regulation

Question 22

how is tachyphylaxis related to receptor regulation?

Answer 22

when responsiveness to a drug diminishes rapidly after administration of a drug like acute tolerance