COMT-INHIBITORS

Question 1

name the 2 drugs?

Answer 1

tolcapone
-better efficacy
entacapone
-does not cross the BBB

Question 2

this class of drugs is useful in managing L-Dopa fluctuations (dyskinesias)

no effect when given alone

Answer 2

COMT-Inhibitors

Question 3

adverse drug reactions?

Answer 3

same as L-Dopa
need to lower L-Dopa dose by 30% for first 48 hrs
-since w/ COMT inhibitor you drive up the amount of DA liver toxicity (tolcapone)
-need to monitor liver fn tests