ANTIPLATELET PHARMACOLOGY

Question 1

this is the major cause of morbidity and mortality in western societies with 500,000 deaths in the US each year

Answer 1

atherosclerosis

Question 2

this is the initiating event in the development of an acute MI

Answer 2

thrombus

Question 3

name this type of hemostasis…

vascular endothelium damage to platelet adhesion, activation and aggregation

Answer 3

primary hemostasis

Question 4

vascular sub endothelium collagen exposure affect primary hemostasis how?

Answer 4

stimulators of platelet activation

Question 5

stimulators of platelet aggregation?

Answer 5

thromboxane A2
ADP
serotonin

Question 6

name this type of hemostasis…

coagulation proteins to coagulation cascade

Answer 6

secondary hemostasis

Question 7

what are the classes of anti platelets?

Answer 7

cyclo oxygenate inhibitors

selective ADP inhibitors

Question 8

what are the two important cycle oxygenate inhibitors?

Answer 8

aspirin

NSAIDs

Question 9

MOA of what cyclo oxygenate inhibitors

irreversible inhibitor of platelet CO

duration of effect is the time span of the platelet (6-10 days)

Answer 9

aspirin

Question 10

MOA of what cyclo oxygenate inhibitors

reversible inhibitor of platelet CO

not useful clinically due to short duration

Answer 10

NSAIDs

Question 11

what are the important side effects of cycle oxygenate inhibitors?

Answer 11

tinnitus with high levels

Question 12

meds that increase risk of bleeding?

effect of methotrexate and valproic acid?

Answer 12

warfarin, NSAIDs

cause an increase in the dose