BETA LACTAMS IV

Question 1

new beta lactamase inhibitor

bind to certain beta lactamases rendering them inactive

may be active KPC

Answer 1

ceftazidime/avibactam

Question 2

a new cephalosporin with similar structure to ceftazidime

Answer 2

ceftolozone/tazobactam

Question 3

uses are for MDR pseudomonas

ESBL producing enterobacterrs

Answer 3

cephalosporins + beta lactamases inhibitor combos

Question 4

cephalosporins + beta lactamase inhibitor combos are good spectrum antibiotics against?

Answer 4

pseudomonas

enteric GNRs

Question 5

this is a monobactam that is safe in beta lactam allergies

similar spectrum of activity as ceftazidime

widely throughout the body

renal eliminated

reserved for allergies to beta lactams

good spectrum against pseudomonas

Answer 5

aztreonam

Question 6

this is the broadest spectrum antibiotic

ertapenum
meropenem
doripenem
imipenem/cilastin

nosocomial infections, mixed aerobic, anaerobic infections, ESBL producing organisms

good spectrum against MSSA, strep, enterobacter

Answer 6

carbapenems

Question 7

this is carbapenem beta lactamase inhibitor that protects meropenem from degradation by certain serine beta lactamases

FDA indication for cUTI including pyelonephritis

Answer 7

meropenem/vaborbactam