ANTIMICROBIAL MEDS II

Question 1

TB Treatment regimen?

initial therapy

Answer 1

treat for 8 weeks

rifampin
isoniazid
pyrazinamide
ethambutol

Question 2

TB Treatment regimen?

maintenance

Answer 2

treat for 18 weeks

rifampin
isoniazid

Question 3

TB Treatment regimen?

latent

• preferred (traditional)
• preferred (short course)

Answer 3

isoniazid for 9 months

isoniazid + rifapentine weekly for 12 weeks

Question 4

• MDR-TB (multi-drug resistant TB)
• Lack of response to first-line agents
• Serious treatment-limiting adverse reactions to first-line agents

Answer 4

Streptomycin

Question 5

Streptomycin main ADRs?

Answer 5

Ototoxicity
Nephrotoxicity
Vertigo

Question 6

• chronic, progressive skin, neurological disorder of high
morbidity and stigma
• obligate intracellular pathogen, ~2 week doubling time, 2-5 year incubation period

Answer 6

Mycobacterium leprae
Hansen Disease (leprosy)

Question 7

name this disease based of the cardinal signs?

• Localized skin lesions
• Nerve trunk thickening (e.g., great auricular nerve)
• AFB demonstrated in lesions, usually skin or nerve

Answer 7

Hansen Disease (leprosy)

Question 8

Hanson disease treated with?

Answer 8

combo therapy x 12 months

Dapsone
Clofazimine
Rifampin

Question 9

• MOA: inhibits folate synthesis
• G6PD level assessment recommended before use

also treats Pneumocystis jivroveci

Answer 9

Dapsone

Question 10

• MOA: bind preferentially to mycobacterial DNA to inhibit replication/
growth
• Procured only via investigational new drug (IND) protocol

Answer 10

Clofazimine

Question 11

MOA
• Erythema nodosum leprosum often develops
• Erythema nodosum leprosum may be suppressed by thalidomide

Answer 11

Thalidomide