TERMS

Question 1

prevents microtubules from elongating which disrupts cellular structure, growth and division

well tolerated

spectrum for cestodes adn nematodes

Answer 1

albendazole and mebendazole

Question 2

scabies is a hypersensitivity reaction to mite feces in skin capillaries and so this drug is used to bind to parasitic NMJ leading to paralysis and death from starvation

very well tolerated (fever, myalgia, hypotension)

spectrum for ectoparasites and nematodes

mazzoti reaction

Answer 2

ivermectin

Question 3

this reaction is seen in onchocerciasis with hypotension, fever, pruritis, bone and joint pain

Answer 3

mazzoti reaction

Question 4

drug for schistosomiasis with MOA: increases permeability of trematode and cestode cell membranes to calcium leading to paralysis and dislodgment then to death

ADR
HA and GI intolerance
rash and pruritis

spectrum for schistosomiasis, clonorchiasis, opisthorchiasis

Answer 4

praziquantel