MACROLIDES

Question 1

group of closely related compounds characterized by a macrocyclic ring with deoxy sugars attached

what is this class?

Answer 1

macrolides

Question 2

what are the types of macrolides?

Answer 2

erythromycin
clarithromycin
azithromycin

Question 3

important note about metabolism?

Answer 3

caution if severely impaired hepatic function

Question 4

which type of macrolide has the most side effects?

Answer 4

erythromycin

Question 5

what are the ADRs?

Answer 5

GI-worse with erythromycin
hepatic-erythromycin causes cholestatic hepatitis

*cardiotoxicity-QT prolongation, alters K+ channels

Question 6

erythromycin and clarithromycin are inhibitors of what enzymes?

which one doesn’t inhibit this?

Answer 6

CYP3A4

azithromycin

Question 7

preg category?

Answer 7

azithromycin and erythromycin-B

clarithromycin-C

Question 8

what quinolone is this?

inhibits the sigma subunit of bacterial RNA polymerase inhibiting protein synthesis leading to cell death

Answer 8

fidaxomicin

Question 9

what are the indications for fidaxomicin?

Answer 9

C diff associated diarrhea