SELECTIVE A1 ADRENERGIC BLOCKERS AND CENTRAL ACTING

Question 1

what are the selective A1-adrenergic blockers?

Answer 1

doxazosin
prazosin
terazosin
tamsulosin (prostate selective)

Question 2

selective A1-adrenergic blockers MOA?

Answer 2

block peripheral a1 receptors

decrease after load of the heart

decrease peripheral vascular resistance

Question 3

side effects of selective A1-adrenergic blockers?

Answer 3

orthostatic hypotension-first dose effect

Question 4

indications of selective A1-adrenergic blockers?

Answer 4

hypertension
peripheral vascular disease
benign prostatic hypertrophy

Question 5

drug interactions of selective A1-adrenergic blockers?

Answer 5

beta blockers may exacerbate first dose response secondary to blunting an increase in blood pressure upon standing

Question 6

what are the alpha blockers used for BPH?

Answer 6

Tamsulosin (Flomax)

Alfuzosin

Question 7

name this alpha blocker for BPH?

alpha 1 A and ID antagonistic effect increases selectivity for prostate

Answer 7

Tamsulosin (Flomax)

Question 8

name this alpha blocker for BPH?

alpha 1 selective antagonist approved for BPH

Answer 8

Alfuzosin

Question 9

alpha receptor blockers produce what is known as?

Answer 9

first dose or phenomenon

Question 10

patients require the addition of these meds to help blunt sodium and water reabsorption?

Answer 10

diuretics

Question 11

for treatment of heart failure these blocker types are used as adjunctive therapy and not primary therapy secondary to the development of tachyphylaxis

Answer 11

alpha 1 receptor blockers

Question 12

selective A1-adrenergic blockers have no deleterious effects on lipid profiles, T/F?

Answer 12

T

Question 13

which of the receptors discussed is presynaptic?

Answer 13

alpha 2

Question 14

what are the central acting alpha 2 adrenergic. receptor agonist?

Answer 14

clonidine
guanabenz
guanfacine
methyldopa

Question 15

what is the MOA of alpha 2 adrenergic. receptor agonist?

Answer 15

alpha 2 receptors located in the CNS. Pre synaptic receptors decreasing sympathetics lowering blood pressure

Question 16

side effects of the central acting alpha 2 adrenergic. receptor agonist?

methyldopa?

Answer 16

sedation
drowsiness
dizziness
dry mouth

same, drug induced fever and lupus

Question 17

major indication of alpha 2 adrenergic receptor agonist?

Answer 17

heroin withdrawal (clonidine)

hypertension

Question 18

contraindication of alpha 2 adrenergic receptor agonist?

Answer 18

non compliant patients causing rebound effect

hypersensitivity

Question 19

what are the drug interactions of alpha 2 adrenergic receptor agonist?

Answer 19

TCA

beta blockers

Question 20

clonidine, guanfacine and guanabenz (central acting alpha 2 adrenergic. receptor agonist) warning?

Answer 20

should not be discontinued because of rebound hypertension

Question 21

beta blockers worsen rebound hypertension, T/F? so treated with?

Answer 21

T

clonidine

Question 22

this central acting alpha 2 adrenergic receptor agonist has data in the treatment of hypertension in pregnant women with hypertensive emergencies

Answer 22

methyldopa