NON-STATINS Flashcards
1
Q
Things to consider before
adding?
A
Adherence and lifestyle
Statin intolerance
Control of other risk factors
2
Q
non-statin options
A
• Ezetimibe (Zetia) • Bile acid resins -Cholestyramine -Colestipol -Colesevelam • Niacin • Fibrates -Fenofibrate (Tricor) -Gemfibrozil • Omega-3-acid ethyl esters • Mipomersen • Lomitapide • PCSK9 inhibitors
3
Q
LDL remains at or above _____? clinicians may consider adding _____?
If LDL remains elevated, it is reasonable to add a??
A
70 mg/dL despite maximal statin therapy
ezetimibe***
PCSK9 inhibitor***
4
Q
Ezetimibe MOA?
combine with what?
Effectiveness?
ADRs and precaution?
A
Cholesterol Absorption Inhibitor that inhibits a transport protein (NPC1L1) in the small intestines, reducing cholesterol absorption
Combine with statins for additional LDL lowering
Reduction in LDL: 15%-20%
May elevate hepatic transaminases: discontinue if ALT or AST persistently ≥3 x ULN
Headache
Rash
