TERMS Flashcards
what are the different anti parasites?
anti malaria
anti helminths
these quinolones can cause cardiotoxicity like QTc prolongation
MOA:interfere with heme sequestration or inactivating the toxic heme
chloroquine, mefloquine, quinidine, quinine, primaquine
these quinolones?? have an MOA that:
blood schizonticide
gametocidal against P vivax and P ovale
resistance high in falciparum in SE Asia but there are drugs used as parenteral and oral treatments, not a prophylaxis
co-administered with??
quinidine and quinidine, quinidine is a stereoisomer of quinine
tetracycline, doxycyline, clindamycin
this quinolone is also a blood schizonticide
chloroquine
this quinolone is effective for many chloroquine resistant strains of P falciparum and is considered a chemophrophylactic in malaria endemic regions
also a blood schizonticidal used as a treatment and prophylaxis of the susceptible species including chloroquine resistant ones
mefloquine
this quinolone is considered by WHO as a drug that may block transmission of P falciparum as gametocytocidal agent
MOA: DOC for eradication of dormant liver forms of P vivax and P ovale and effective against gametocytes of P falciparum
primaquine
these artemisinin derivatives bind iron which leads to the generation of free radicals that damage parasite proteins
also schizonticides
artemether
arteether
dihydroartemisinin
artesunate
name the inhibitor of folate synthesis based on the MOA?
these are agents used in combination for synergism
sulfadoxine
pyrimethamine
proguanil
name the inhibitor of folate synthesis based on the MOA?
pyrimethamine targets dihydrofolate reductase and sulfadoxine acting on dihydropteroate synthase leading to inhibition of DNA synthesis
used in combo with quinine in the treatment of chloroquine-resistant P falciparum malaria
severe cutaneous reactions
sulfadoxine-pyrimethamine
name the inhibitor of folate synthesis based on the MOA?
atovaquone blocks the parasite mitochondrial electron transport chain and inhibits parasite dihydrofolate reductase through cycloguanil
atovaquone-Proguanil
what are the amebicides?
iodoquinol
tinidazole
what is this amebicide?
chelates ferrous ions that are necessary for metabolism and treatment for intestinal amebiasis
iodoquinol
what is this amebicide?
readily absorbed and widely distributed (even CNS)
used for E histolytica tissue infections, giardiasis, trichomoniasis
tinidazole
what is this class of drug used for disrupting incorporation of nucleotides into RNA and DNA
inhibits biosynthesis of DNA< RNA, protein, and phospholipid
clinical use for treatment of moderate to severe pneumocystis jirovecii infections
2nd line treatment for pneumocystis pneumonia
pentamidine
