MAO-B INHIBITORS

Question 1

name the three drugs?

Answer 1

rasagaline
selegiline
safinamide

Question 2

these metabolize?

Answer 2

DA so, it increase amount of DA in the system

Question 3

MOA?

Answer 3

irreversibly bind to MAO-B

long duration of action (since MAO-B synthesis is slow)

Question 4

mono therapy use?

Answer 4

early stages of PD

Question 5

given with what to increase leva dopa for PD treated?

Answer 5

leva dopa

Question 6

contraindicated when?

Answer 6

use w/in 10 days prior to elective surgery increasing risk of serotonergic syndrome

Question 7

avoid?

Answer 7

seratonergic drugs
tyramine
psychostimulants

Question 8

adverse drug rxns?

Answer 8

nausea, confusion, insomnia
impulsivity
hallucinations
orthostatic hypotension

Question 9

for amantadine:

works as?

Answer 9

antiviral agent w/ anti-parkinsonian activity

Question 10

for amantadine:

MOA?

Answer 10

shows anticholinergic effects

Question 11

for amantadine:

used for?

Answer 11

tremor relief

Question 12

for amantadine:

adverse effects?

Answer 12

livedo redicularis
-stop amantadine

peripheral edema
-use w/ caution in heart failure