HISTAMINE HIGH YIELD

Question 1

this functions as a NT and neuromodulator and mediates allergic and inflammatory reactions

• local vasodilation, release of C reactive proteins and antibodies
• chemotactic response

located in mast cells and basophils

Answer 1

histamine

Question 2

what are the histamine stores?

Answer 2

mast cell histamine

• nose
• mouth
• feet
• blood vessels
• internal body surfaces

nonmast cell histamine

• brain
• fundal cells of the stomach

Question 3

what are the types of histamine release?

Answer 3

immunologic
chemical
mechanical

Question 4

whats the histamine MOA? name the two important ones

Answer 4

HI, smooth muscle, endothelium, brain
-acute allergic response
H2, gastric mucosa, cardiac muscle, mast cells, brain
-GI gastric acid secretion

Question 5

what is the effect of histamine on organ systems?

Answer 5

cardiovascular 
GI tract
bronchiolar smooth muscle
nervous system
skin
genitourinary
CNS