ANTIPLATELET PHARMACOLOGY II Flashcards
what are the ADP inhibitor prodrugs?
significance
clopidogrel
prasugrel
bind P2Y12 receptor
irreversible inhibitor
what are the ADP inhibitor non-prodrugs?
significance
ticagrelor
cangrelor
reversible inhibitor
ADP receptor inhibited on the surface of the platelet which prevents the expression of the GPIIB/IIIa receptor by these meds
what is the affect of inhibiting the ADP receptors?
clopiddogrel
prasugrel
prevent ADP induced platelet aggregation
side effects of:
clopidogrel and prasugrel
rash
bleeding
diarrhea
side effects of:
ticagrelor
dyspnea
ventricular pauses
bleeding
side effects of:
cangrelor
bleeding
dyspnea
o Decrease stroke, MI and peripheral arterial thrombosis in patients with previous history of these disease
o Used in combo with ASA in patients who’ve undergone coronary artery stent placement to prevent thrombus
formation
indication for?
Clopidogrel
indication for?
o Reduces rate of thrombotic CV events in patients who are to be managed with percutaneous coronary
intervention (PCI) for unstable angina (UA), non ST-segment elevation MI, or ST-elevation MI
Prasugrel
indication for?
o Used in combo with ASA for secondary prevention of thrombotic events in patients with unstable angina, non
ST-elevation MI, or ST-elevation MI managed medically or with percutaneous coronary intervention and/or
coronary artery bypass graft
Ticagrelor
indication for?
o Percutaneous coronary intervention
▪ Adjunct to PCI to reduce risk of periprocedural MI, repeat coronary revascularization, and stent
thrombosis in patients who haven’t been treated with a P2Y12 platelet inhibitor and are not being
given a glycoprotein IIb/IIIa inhibitor
Cangrelor
all P2Y12 receptor meds like clopidogrel and prasugrel have drug interactions with?
ASA
warfarin
anticoagulants
NSAIDs
ticagrelor has drug interaction with?
CYP3A4 inhibitors or inducers
