FLOUROQUINOLONES Flashcards
bactericidal, concentration dependent…T/F?
T
topoisomerase II targets?
gram negative microbes
topoisomerase IV targets?
gram positive microbes
in the mechanism of resistance, this arises from?
alterations in target enzymes (topo II and IV) and changes in drug entry and efflux
what are the types of fluoroquinolones?
ciprofloxacin levofloxacin moxifloxacin ofloxacin delafloxacin
significance of moxifloxacin?
doesn’t cover P. aeruginosa
only fluoroquinolone that covers anaerobes
which of the fluoroquinolones has the broadest coverage?
delafloxacin
MSSA MRSA Strep Pseudomonas E. Faecalis Atypical
MRSA?
only delafloxacin
S. pneumoniae, E faecalis, MSSA/CoagNS coverage?
levo, moxi, dela
streptococcus sp?
delafloxacin is best
T/F, ciprofloxcin is a respiratory quinolone?
F
cardio effect of fluoroquinolones?
QT prolongation
black box warnings?
tendon rupture/tendonitis
peripheral neuropathy
myasthenia gravis
CNS effects
patient infections where FQs are used if no alternative tx available?
acute bacterial sinusitis
acute bacterial exacerbation of chronic bronchitis
uncomplicated UTI
major drug interactions?
what inhibits CYP1A2?
divalent/trivalent cations reducing absorption of quinolones
QT prolonging agents having toxicities
CYP interactions
ciprofloxcin
