LAST MINUTE COMMON TOXIC SYNDROMES Flashcards
10 grams is a lethal dose
induction of CIP2EI
this the treatment for acetaminophen overdose?
N-acetylcysteine
opioid overdose, decreases CNS activity, respiratory depression
naloxone (opioid antagonist)
BZD causes CNS depression
flumazenil
tricyclic antidepressants are one of the most common causes of life threatening drug overdoses
sedation, tachycardia, hypotension, seizures, dilated pupils\
inhibits cardiac sodium channels
sodium bicarbonate
what can beta blockers be treated with?
glucagon
amphetamine and other stimulants can be treated with?
1) seizures or agitation
2) respiratory
3) hypertension
4) hyperthermia
1) BZD
2) ventilatory support
3) antihypertensives (labetalol)
4) cooling
carbon monoxide poisoning is treated with?
100% oxygen
what can we create methanol and ethylene glycol sickness with?
ADH inhibitor: fomepizole
organophosphate poisoning can be treated with what drugs?`
atropine with pralidoxime (2PAM)
how do we use prophylaxis for organophosphate?
use pyridostigmine (reversible cholinesterase inhibitor) than once affected swap to atropine and 2 pam
inducer of CYP enzymes?
barbiturates st johns wort carbamazepine rifampin alcohol phenytoin phenoxybenztoin
inhibitor of CYP enzymes?
grapefruit juice macrolides cimetidine SSRIs azoles fluroquinolones amiodorone ritonavir isoniazid
foods high in tyramine interact with what?
`MAOIs; antidepressant
food high in vitamin K interact with what?
warfarin
food rich in pyridoxine increases?
metabolize increase of levodopa (Parkinson’s)
