FIRST GEN ANTIPSYCHOTICS Flashcards
name the gen off this description?
typical antipsychotics
first gen
name the gen off this description?
atypical antipsychotics
second gen
mech of action?
Decrease dopamine neurotransmission through D2 blockade
same efficacy, differ in potency and side effects
low potency?
cheating thieves are low
chloropromazine
thioridazine
high potency?
hal tries to fly high
trifluroperazine
thiothexene
fluphenazine
haloperidol
blocking dopamine also has extrapyramidal symptoms?
dystonia- spasms of the muscles of the face, tongue, neck and back
akathisia-motors, restlessness. pacing
Parkinsonism-rigidity, tremor, shuffling gait
tardive dyskinesia
involuntary movements- lip smacking, jaw movements, darting of tongue
could become irreversible so must treat early
dystonia treatment?
anticholinergic
akathisia treatment?
beta blocker
Parkinsonism treatment?
anticholinergic
tardive dyskinesia treatment?
reduce antipsychotic dose, discontinue, switch
blocking the dopamine also has increased prolactin secretions from the anterior pituitary
sexual dysfunction, menstrual irregularities, osteoporosis
treatment: reduce the dose, discontinue or switch
hyperprolactinemia
FGA affects what receptors?
M1-anticholinergic side effects
H1-sedation, weight gain
Adrenergic 1-orthostatic hypotension
dopamine 2-therapeutic efficacy
early onset EPS?
late onset EPS?
dystonic reaction
pseudoparkinsonism
akathisia
tardive dyskinesia
EPS symptoms are due to blockage of DA receptors in what pathway?
nigrostriatal pathway
name this EPS symptoms?
unvoluntary movements like lip smacking, jaw movements, and darting of tongue. Purposeless quick movements of the limbs may occur
tardive dyskinesia
