ADRENERGIC AGENTS HIGH YIELD

Question 1

epinephrine acts on what receptors?

Answer 1

a1
a2
b1
b2

Question 2

effects of epi?

Answer 2

vasoconstrictor

cardiac stimulant

Question 3

name this receptor affected by epi?

increased BP through increased chronotropic and inotropic effects, increases CO

Answer 3

b1

Question 4

name this receptor affected by epi?

vasoconstriction, increases peripheral resistance

Answer 4

a1

Question 5

name this receptor affected by epi?

skeletal muscle blood vessel dilation; relieves bronchospasms (respiratory smooth muscle)

Answer 5

b2

Question 6

what line agent is epi in relation to treating shock?

Answer 6

2nd line agent

Question 7

what are the therapeutic uses?

Answer 7

anaphylaxis/hypersensitivity
cardiac arrest and asystole
bradycardia
local anesthetic, hemostatic, dental

Question 8

antidote to vasopressor extravasation?

Answer 8

phentolamine

Question 9

name this drug:

direct acting, non-selective
alpha 1-peripheral vasoconstriction
beta 1- minimal effect on CO, HR, contractility

Answer 9

norepinephrine

Question 10

for norepinephrine use on shock, what line of meds is this?

Answer 10

first line

Question 11

name this nonselective B agonist, structurally related to epi, synthetic?

Answer 11

isoproterenol

Question 12

name this precursor to norepinephrine, regulates movements, reward motivated, direct acting, non selective

a1,a2,b1,d1,d2

Answer 12

dopamine

Question 13

dopamine low dose(1-5 mcg/kg/min) effects?

Answer 13

increase urine output and Na excretion

increase GFR

Question 14

dopamine medium dose(5-10 mcg/kg/min) effects?

Answer 14

positive inotrope
increase CO, BP
more a1 stimulation at 10 mcg/kg/min

Question 15

therapeutic uses of dopamine?

Answer 15

shock

advanced heart failure

Question 16

name this selective B1 agonist:

synthetic catecholamine, direct acting

positive cardiac effects useful in low output states

produces peripheral vasodilation

Answer 16

dobutamine

Question 17

therapeutic uses of dobutamine?

Answer 17

refractory heart failure

cardiogenic shock

Question 18

name this selective A1 agonist:

synthetic, direct acting

unlike endogenous catecholamines, it is not metabolized by COMT

pure A1 stimulation

Answer 18

phenylephrine

Question 19

therapeutic uses of phenylephrine?

Answer 19

hypotension/shock
anesthesia induced hypotension
mydriasis
nasal decongestant