ADRENERGIC AGENTS HIGH YIELD Flashcards
epinephrine acts on what receptors?
a1
a2
b1
b2
effects of epi?
vasoconstrictor
cardiac stimulant
name this receptor affected by epi?
increased BP through increased chronotropic and inotropic effects, increases CO
b1
name this receptor affected by epi?
vasoconstriction, increases peripheral resistance
a1
name this receptor affected by epi?
skeletal muscle blood vessel dilation; relieves bronchospasms (respiratory smooth muscle)
b2
what line agent is epi in relation to treating shock?
2nd line agent
what are the therapeutic uses?
anaphylaxis/hypersensitivity
cardiac arrest and asystole
bradycardia
local anesthetic, hemostatic, dental
antidote to vasopressor extravasation?
phentolamine
name this drug:
direct acting, non-selective
alpha 1-peripheral vasoconstriction
beta 1- minimal effect on CO, HR, contractility
norepinephrine
for norepinephrine use on shock, what line of meds is this?
first line
name this nonselective B agonist, structurally related to epi, synthetic?
isoproterenol
name this precursor to norepinephrine, regulates movements, reward motivated, direct acting, non selective
a1,a2,b1,d1,d2
dopamine
dopamine low dose(1-5 mcg/kg/min) effects?
increase urine output and Na excretion
increase GFR
dopamine medium dose(5-10 mcg/kg/min) effects?
positive inotrope
increase CO, BP
more a1 stimulation at 10 mcg/kg/min
therapeutic uses of dopamine?
shock
advanced heart failure
name this selective B1 agonist:
synthetic catecholamine, direct acting
positive cardiac effects useful in low output states
produces peripheral vasodilation
dobutamine
therapeutic uses of dobutamine?
refractory heart failure
cardiogenic shock
name this selective A1 agonist:
synthetic, direct acting
unlike endogenous catecholamines, it is not metabolized by COMT
pure A1 stimulation
phenylephrine
therapeutic uses of phenylephrine?
hypotension/shock
anesthesia induced hypotension
mydriasis
nasal decongestant
