a/B ADRENERGIC RECEPTOR ANTAGONIST

Question 1

alpha/beta adrenergic receptor antagonist

Answer 1

labetalol

carvedilol

Question 2

alpha/beta adrenergic receptor antagonist MOA?

Answer 2

these agents are considered third generation beta blockers

they posses non selective beta blocking activity like propranolol and alpha blocking activity like prazosin

effects seen:

• decrease heart rate
• decrease contractility
• vasodilation

Question 3

side effects of alpha/beta adrenergic receptor antagonist?

Answer 3

bradycardia
hypotension
dizziness
fatigue

Question 4

labetalol indication?

Answer 4

hypertension
hypertension emergencies
acute aortic dissection
hypertension associated with pheochromocytoma

Question 5

carvedilol indication?

Answer 5

hypertension

adjunctive therapy for mild-moderate heart failure

Question 6

main drug interaction of carvedilol?

Answer 6

digoxin

Question 7

this alpha/beta adrenergic receptor antagonist is an excellent alternative to patients with acute aortic dissection?

Answer 7

labetalol

Question 8

this labetalol route of admin has more beta blocking activity than alpha blocking activity with a ratio of 7:1. where as the oral formulation has a 3:1 ratio

Answer 8

IV labetalol

Question 9

this is the first beta blocker indicated for adjunctive treatment of heart failure

Answer 9

carvedilol

Question 10

MOA of nebivolol?

Answer 10

beta 1 selective beta blocker with nitric oxide dependent vasodilation