GLYCOPEPTIDES

Question 1

what are the types?

Answer 1

vancomycin
daptomycin

*dalbavancin and oritavancin

Question 2

what is the mechanism of vancomycin?

bactericidal or bacteriostatic

Answer 2

binds to the D-ala-D-ala chain on peptidoglycan in the cell wall preventing elongation

Question 3

how is vancomycin excreted?

Answer 3

renally so adjustments are required

Question 4

vancomycin has good spectrum against?

Answer 4

MSSA. MRSA, Strep

C. diff when used orally

Question 5

what are the clinical uses of vancomycin?

Answer 5

SSTI
bone and joint
resp infections
endocarditis
bacteremia
CNS

*serious infections caused by beta lactam resistant gram positive bugs

Question 6

major ADR of vancomycin?

Answer 6

red man syndrome

also

nephrotoxicity
ototoxicity
preg C(IV), B(oral)

Question 7

MOA of daptomycin?

bactericidal or bacteriostatic

Answer 7

binds to membrane and causes depolarization leading to death

bactericidal

Question 8

metabolism/excretion of daptomycin?

Answer 8

penetrates deep into lung, not useful for pneumonia

renally eliminated

Question 9

daptomycin has good spectrum against?

Answer 9

MSSA
MRSA
strep

Question 10

what are the clinical uses of daptomycin?

Answer 10

complicated SSTI
S. aureus bacteremia
joint OM
meningitis