MMD DRUGS- SNRI

Question 1

• FIRST LINE FOR MDD
• -other indications like GAD, diabetic neuropathy, chronic MSK pain
• Inhibition of SERT and NE
• smilar efficacy to SSIRs

what is this class of drug

Answer 1

SNRI

Question 2

Indicated for MDD, GAD, and Multiple Pain indications
-diabetic neuropathy, fibromyalgia, chronic msk pain

avoid in patients w/ liver toxicity

Answer 2

duloxetine

Question 3

only indicated for fibromyalgia

Answer 3

milnacipran

Question 4

adverse effects?

Answer 4

increase BP, HR
-Increased NE

xerostomia, constipation, urinary retention
-anticholinergic like effects (think fight or flight)

Question 5

name this SNRI

several uses for MDD, GAD, SAD

5-HT reuptake at lower doses <150 mg/day

NE reuptake at >150 mg/day

Answer 5

venlafaxine

Question 6

name this SNRI

active metabolite of venlafaxine

tablet shell may appear in stool

similar side effects as venlafaxine

Answer 6

desvenlafaxine

Question 7

name this SNRI

enantiomer of milnacipran

higher activity at NRI than SRI

place in therapy

Answer 7

levomilnacipran

Question 8

black box warning?

Answer 8

like SSRIs, suicidality