PENICILLINS

Question 1

MOA of beta lactams?

time dependent killing, T/F?

Answer 1

inhibits the synthesis of the bacterial peptidoglycan cell (bactericidal)

T

Question 2

what part of bacteria do the beta lactams bind?

Answer 2

transpeptidase that binds to bacterial peptidoglycans

Question 3

pencillan binding mods is reason for this type of bacteria?

Answer 3

MRSA

Question 4

what is the significance of probenecid?

Answer 4

blocks secretion of penicillins

Question 5

this penicillin used for severe infection?

dosing?

common uses?

Answer 5

penicillin G, aqueous crystalline

around the clock dosing due to short half life to remain above the MIC

neurosyphilis, endocarditis, meningitis, osteomyelitis

Question 6

why is penicillin G benzathine significant?

Answer 6

IM injection only

Question 7

this penicillin used for less severe infection?

dosing?

common uses?

Answer 7

penicillin V, orally

125-500 mg q6-8 hours

streptococcal pharyngitis, otis media, erysipelas

Question 8

good spectrum against?

Answer 8

strep sp
treponema pallidium
neisseria meningitidis
pasteurella multocida