LAST MINUTE IMPORTANT GENES

Question 1

poor metabolizer, seen in blacks and whites

beta blockers, tamoxifen, antipsychotics

Answer 1

CYP2D6

Question 2

poor metabolizers, asians

omeprazole, clopidogrel

Answer 2

CYP2C19

Question 3

warfarin metabolized by this allele

Answer 3

CYP2C9

Question 4

succinycholine metabolized by this?

Answer 4

pseudocholinesterase

Question 5

deficiency of this enzyme leads to hemolytic anemia

Answer 5

G6P dehydrogenase

Question 6

inactive allele exhibits pancytopenia?

Answer 6

thiopruine S-methyltransferase

Question 7

tachyphalaxis as a result of incidence of this allele

regular albuterol use

Answer 7

Arg16

Question 8

encodes for P glycoprotein, a transporter protein

Answer 8

ABCB1

Question 9

treatment for malignant hypertension?

Answer 9

dantrolene

Ryr1 affected

Question 10

because irinotecan is a chemotherapeutic, this allele inactivates an active metabolite of irinotecan?

Answer 10

UGT1A1