MMD DRUGS- SSRI

Question 1

first line for MDD (and GAD, PTSD, PD-panic disorder)
generally well tolerated

what is this drug class?

Answer 1

SSRI

Question 2

what serotonin transporter is blocked, preventing reuptake?

Answer 2

inhibit 5-HT

Question 3

name this drug

• MOST ACTIVATING SSRI
• Strong CYP2D6 inhibitor
  o Beta-blockers
  o Tricyclic antidepressents
  o Tramadol
  o Opiods
  long half life
  preg cat C

Answer 3

Fluoxetine

Question 4

name this drug

• More sedating SSRI ß what makes it very different from the other SSRIs
• Strong CYP1A2 inhibitor
• INDICATION is only OCD

Answer 4

Fuvoxamine

Question 5

name this drug

GI upset more prevalent
more activating
no CYP inhibition
safest SSRI for breastfeeding

Answer 5

Sertraline

Question 6

name this drug

• Dose-dependent QT prolongation
• Less drug interactions than other SSRIs

Answer 6

Citalopram

Question 7

name this drug

• Dose-dependent QT prolongation
• Less drug interactions than other SSRIs
• no clinical advantage over citalopram
• no CYP inhibition

Answer 7

Escitalopram

Question 8

name this drug

weight gain
sex dysfx
sedation

strong CYP2D6

highest affinity for SERT with some NET inhibition; also blocks M1 receptor and DA reuptake

Answer 8

paroxetine

Question 9

major side effects?

Answer 9

interferes with serotonin activity in platelets

impair platelet aggregation

Question 10

Black box warning?

Answer 10

suicidal thinking in patients with MDD and psychiatric disorders