SCHIZOPHRENIA

Question 1

what is this hypothesis?

drugs that increase dopamine can cause psychosis so blocking dopamine receptors is the clinical efficacy

Answer 1

dopamine hypothesis

Question 2

treatment approach/goals

pretreatment?
goals?

Answer 2

• mental status exam
• neuro exam
• exclude causative agents like-cocaine, amphetamines, LSD, corticosteroids

acute stabilization
stabilization
maintenance

Question 3

positive symptoms like delusions, hallucinations, disorganized speech, disorganized behavior are related to increased dopaminergic activity in the?

Answer 3

mesolimbic region

Question 4

negative symptoms like affective flattening, alogia, avolition, anhedonia are related to decreased dopaminergic activity in the?

Answer 4

mesocortical region

Question 5

for this, in terms of creatine, what must be considered and excluded?

Answer 5

drugs

• cocaine
• amphetamines
• LSD
• corticosteroids
• methylphenide

Question 6

treatment goals occur in what phases?

Answer 6

acute stabilization
stabilization
maintenance

Question 7

antipsychotic uses?

Answer 7

schizophrenia
bipolar
psychotic depression
psychoses
drug induced psychosis

Question 8

first gen antipsychotics are considered?

Answer 8

typical antipsychotics

Question 9

second gen antipsychotics are considered?

Answer 9

atypical antipsychotics

Question 10

FGA MOA?

how do agents differ?

Answer 10

decreases central DA neurotransmission through D2 blockade also antagonizes muscurinic cholinergic, a2, H1 receptors

based on potency and side effects

Question 11

FGA low potency?

FGA high potency?

Answer 11

chlorpromazine
thioridazine

fluphenazine
haloperidol