MISC SYMPATHOMIMETIC AGONISTS HIGH YIELD

Question 1

name this a1 selective agonist, a direct acting sympathomimetic:

used for symptomatic orthostatic hypotension; hemodialysis induced hypotension

dosing 2.5 to 10 mg TID PO

hypertension is an adverse effect

Answer 1

midodrine

Question 2

what are the misc sympathomimetic agonists?

Answer 2

midodrine
ephedrine
pseudoephedrine
amphetamines
tyramine

Question 3

Midodrine is what type of agonist?

Answer 3

alpha 1-selective agonist

Question 4

this has alpha and beta receptors and causes release of NE from tissue stores?

Answer 4

ephedrine

Question 5

what is the important adverse effect of ephedrine?

Answer 5

moderate ability to cross into the CNS

Question 6

what is significant of the pseudoephedrine? AE?

Answer 6

enantiomer of ephedrine
-agonist of alpha and beta

CNS stimulation, nervousness

Question 7

these types stimulate release of DA and NE and blocks reuptake

Answer 7

amphetamines

Question 8

this is very similar to amphetamine?

Answer 8

methamphetamine

Question 9

clinical use of amphetamines?

Answer 9

ADHD

Question 10

important AE of amphetamines?

Answer 10

CV: tachycardia, HTN

CNS: psychotic episodes

GI: dry mouth

*highly addictive

Question 11

this med is inactivated by monoamine oxidase?

Answer 11

tyramine