ANTIBIOTICS I Flashcards
this folate antagonist interferes with folic acid synthesis and growth by inhibiting formation of dihydrofolic acid
sulfamethoxazole
the folate antagonist inhibits formation of THF acid?
trimethoprim
folate antagonist good spectrum against?
MSSA MRSA Coag-neg staph strep pneumo jiroveci t gondii
folate antagonist treatment for stentotophomonas maltophilis, non fementing GN rod found in water and soil causing pneumonia, blood problems with RFs from catheter
TMP/SMX
folate antagonist treatment for yeast like fungus pneumocystis jiroveci causing related pneumonia, RFs being HIV with subacute onset of fever?
is prophylaxis indicated? if so, what?
what does this organism need to synthesize on its own?
TMP/SMX
TMP/SMX, CD4 count less than 200
folic acid
caution with patients taking TMP/SMX?
hyperkalemia
avoid use if patient has hx of severe reactions like TENS, SJS
aminoglycosides bind to what ribosomal subunit?
bactericidal or bacteriostatic?
30S
bactericidal
important to PK/PD note about aminoglycosides?
renal adjustment
type of aminoglycoside dosing preferred with 3-5 mg given every 8 hours and preferred in patients with ascites, burns, cystic fibrosis
traditional dosing
type of amino glycoside dosing preferred with 5-7 mg given once daily and preferred in most other patients
extended interval dosing
amino glycoside dosing consideration?
concentration dependent
post antibiotic effect
aminoglycosides has good spectrum against?
poor?
gram negative bacteria
atypical
anaerobes
gram positive
major aminoglycosides ADRs?
ototoxicity
nephrotoxicity
neurologic
-myasthenia gravis
plazomicin, an amino glycoside may be active against?
resistant enterobacteriaceae
*ESL carbapenemases E coli k pneumoniae P mirabilis e cloacae
tetracycline main characteristics?
bacteriostatic
30S subunit
