ANTIARRYTHMIC DRUGS I

Question 1

all antiarrhythmics are?

Answer 1

pro-arrhythmic and negative inotropic

Question 2

wolff-parkinson white syndrome is what kind of arrhythmia?

Answer 2

supra ventricular

Question 3

torsade de pointes is what kind of arrhythmia?

Answer 3

ventricular

Question 4

oldest most common less descriptive antiarrhythmic classification?

Answer 4

vaughn williams

Question 5

all the important class Ia drugs?

Answer 5

quinidine

disopyramide

Question 6

all the important class Ib drugs?

Answer 6

mexiletine

Question 7

all the important class Ic drugs?

Answer 7

flecainide

propafenone

Question 8

all the important class III drugs?

Answer 8

amiodarone
dronedarone
sotalol
dofetilide

Question 9

all the important class V drugs?

Answer 9

digoxin

Question 10

all class Ia drugs have the potential to cause?

Answer 10

Torsades de pointes

Question 11

main drug interaction of quinidine, a class Ia drug?

Answer 11

inhibits CYP2D6

Question 12

main considerations of quinidine?

Answer 12

increases AV nodal conduction

Question 13

disopyramide, a class Ia drug has these major side effects?

Answer 13

anticholinergic
heart failure
torsade’s
GI

Question 14

main consideration of disopyramide, a class Ia drug?

Answer 14

may be used in patients with hypertrophic cardiomyopathy

Question 15

mexiletine, a class Ib drug, has this main consideration?

Answer 15

not very effective as a single agent

Question 16

class Ic, a potent sodium channel blocker, has the most important effect on which phase?

affect on CV?

Answer 16

phase 0 of action potential (decreases its slope)

negative inotropy***
bradycardia
heart failure
heart block

Question 17

propafenone, a class Ic drug, has this major side effect?

Answer 17

metallic/bitter taste***
headache
negative inotropy 
cholestatic jaundice
heart block

Question 18

this class III drug is 1/3 less effective than amiodarone?

no iodine w/ a shortened half life of 14 hrs

Answer 18

dronedarone

Question 19

this beta blocker? has what class activity?

Answer 19

sotalol, second most used antiarrhythmic

Question 20

what is the major consideration of sotalol?

how is this eliminated?

Answer 20

torsades

renally eliminated

Question 21

this class III drug is a potassium channel blocker? and has what percent renal elimination?

Answer 21

dofetilide

80%

Question 22

what is significant about the QT interval of dofetilide, a class III drug?

major side effect?

Answer 22

determined before 1st dose

torsades

Question 23

this class V drug? has what type of elimination?

Answer 23

digoxin

P-gp elimination

Question 24

T/F, digoxin, a class V drug, does not convert patients out of AFIB?

Answer 24

T

Question 25

this drug is first line in most patient populations?

Answer 25

amiodarone