MISC AB Flashcards
examples?
clindamycin metronidazole linezolid quinupristin-dalfopiristin chloramphenicol
clindamycin affects what ribosomal subunit?
50s subunit
best uses of clindamycin?
SSTI respiratory coverage against anaerobes GI -PID -inhibits production of toxins (exotoxins, endotoxins), beta lactams used for: S pyogenes S aureus C perfringes
BB warning of clindamycin?
C diff
watery diarrhea
metronidazole mainly used against?
an antiprotozoal drug against anaerobes
since metronidazole cannot be used to treat C diff due to increased resistance, what is used instead?
Vanco PO
Fidexo
metronidazole ADR and preg risk?
inhibitor of what cyp enzyme?
GI
-metallic tast
neuro
preg risk B
disulfiram like reaction occurs if alcohol used
cyp 450
MOA of linezolid?
bacteriostatic for?
bactericidal for?
inhibits bacterial protein synthesis by binding to the P site on 50s ribosomal subunit
staph and enterococci
strep
linezolid good against?
gram positives strep staph, MRSA enterococci E faecalis and E faecium
major adverse hematological effect?
bone marrow suppression
major drug with linezolid interaction causing?
non selective inhibitor of MO for risk of serotonin syndrome
quinupristin-dalfopiristin spectrum?
MOA?
use?
MRSA
E faecium
vancomycin
binds 50s subunit
for multidrug resistant organisms
quinupristin-dalfopiristin adr?
what cyp enzyme is inhibited?
myalgias and arthralgias
CYP3A4
major characteristic of chloramphenicol?
ADRs?
rarely used in US
only in serious infections
bacteriostatic
fatal aplastic anemia
used for serious life threatening infections
Grey Baby Syndrome
