CARDIOVASCULAR PHARMACY

Question 1

this is the major cause of morbidity and mortality in the US for both men and women?

Answer 1

coronary artery disease

Question 2

atrial fibrillation

A-V node re entry tachyarrhyythmia

wolf-parkinson-white

multi focal atrialtachycardia

Answer 2

supra ventricular arrhythmias

Question 3

ventricular tachycardia

ventricular fibrillation

PVC

Answer 3

ventricular arrhythmias

Question 4

BP equation?

Answer 4

BP=CO x SVR

Question 5

CO equation?

Answer 5

CO=HR x SV

Question 6

Heart rate is based on?

Answer 6

sympathetic nervous system

parasympathetic nervous system

Question 7

stroke volume is based on?

Answer 7

preload

afterload

contractility

Question 8

name this receptor?

mostly heart EPI>NE

increase CO, increase chronotrophy, increase inotrophy, increase dromotrophy

Answer 8

B1

Question 9

name this receptor?

EPI>NE

skeletal blood vessels=vasodilation; h/e this may be counterbalanced alpha 1 stimulation

bronchial smooth muscle=vasodilation

Answer 9

B2

Question 10

name this receptor?

adipose tissue, bladder

Answer 10

B3

Question 11

name this receptor?

vascular smooth muscle to arterial and venous vasoconstriction

Answer 11

A1

Question 12

name this receptor?

located in postsynaptic CNS neurons and peripheral vasculature

activation of the receptors in the periphery causes vasconstriction

activation of the receptors in the CNS leads to decrease release of NE from the CNS neurons

Answer 12

A2

Question 13

name this receptor?

vasodilation of renal, splanchnic, coronary vessels

Answer 13

D1

Question 14

for adrenergic modulating meds, what are the nonselective antagonist beta blockers?

Answer 14

propanolol
nadalol
timolol
pindalol

Question 15

for adrenergic modulating meds, what are the B1 selective antagonist blockers?

Answer 15

metaprolol
atenolol
esmolol
acebutolol

Question 16

MOA for non selective agents?

cardiovascular effects

non cardiovascular effects

Answer 16

antagonizes both B1 and B2 receptors thus inhibiting the effects of catecholamines on these receptors

decrease contractility
decrease heart rate

B2 blocking effects, increase peripheral vascular resistance; bronchospasm

Question 17

MOA for selective agents?

cardiovascular effects?

Answer 17

antagonizes B1 receptors to a greater extent than B2 receptors in typical doses

decrease contractility
decrease heart rate

Question 18

side effects?

Answer 18

fatigue
bradycardia
heart block
bronchospasm
may mask the symptoms of hypoglycemia 
rebound effect with abrupt discontinuation

Question 19

what are the indications?

Answer 19

hypertension
ischemic heart disease
antiarrhythmic
heart failure

Question 20

best drugs for treating heart failure?

Answer 20

bisoprolol
carvedilol
metoprolol succinate (XL formulation)

Question 21

absolute contraindications?

Answer 21

hypersensitivity
asthma
heart block greater than the 1st degree

Question 22

drug interactions? name the meds that affect dynamics

Answer 22

meds that slow AV nodal conduction

digoxin
diltiazem
verapamil 
others
NSAIDs

Question 23

why not rifampin, phenobarbital, phenytoin?

Answer 23

induces cyto P450 system

Question 24

affect of abruptly stopping beta blocker use?

Answer 24

rebound effect

Question 25

these patients should be informed to monitor blood glucose when taking beta blockers?

Answer 25

diabetic patients

Question 26

patients with this disease should not take beta blockers?

Answer 26

patients with bronchospastic lung disease

Question 27

a pharmacologic property of Beta blockers is intrinsic sympathomimetic activity, T/F?

Answer 27

T