ADRENERGICS HIGH YIELD Flashcards
the nervous system is comprised of what two systems?
CNS -brain -spinal cord PNS -somatic NS -autonomic NS
what are the two division of the autonomic nervous system?
sympathetic (thoracolumbar)
parasympathetic (craniosacral)
the primary NT of the sympathetic nervous system is _____?
norepinephrine
this NT is released by the adrenal medial and acts as a hormone?
epinephrine
the drugs that mimic the actions of EPI and NE are called?
sympathomimetic
this the immediate precursor to NE?
dopamine
what are the endogenous catecholamines?
dopamine
NE
Epi
this AA is converted to _____, then to _____ which is converted to _____; this is then converted to _____?
tyrosine dopa dopamine NE epi
effects of epi, NE, DA are mediated by?
G protein coupled receptor
a1-a2
b1-b3
d1-d2
what are examples of the autonomic responses?
pupils dilate HR increases RR increases Bronchi dilate Muscles tense Digestion slows Salivation ceases inhibits bladder contraction
adrenergic agonists are drugs that mimim the effects of what drug?
what receptors do these drugs act on?
NE
Epi
alpha and beta receptors
these are the organ system effects of what receptors?
most vascular smooth muscle
vasoconstriction, what is the effect on BP and HR(what mech)
alpha 1 receptor
increased BP
slows HR via baroreflex compensatory mechanism
these are the organ system effects of what receptors?
increased HR, chronotropy, inotropy
beta 1 receptor
these are the organ system effects of what receptors?
respiratory and uterine smooth muscle, skeletal muscle-relaxation/vasodilation
beta 2 receptor
what is a drugs selectivity for a receptor dependent on? effects?
concentration
level of receptor expression in the tissue
