DIURETICS PHARMACOLOGY II

Question 1

potassium sparing diuretics discussed in class?

Answer 1

spironolactone/Eplerenone

amiloride/triamterene

Question 2

spironolactone/Eplerenone MOA?

Answer 2

inhibits aldosterone effects in the cortical collecting tubule and late distal tubule

Question 3

amiloride/triamterene MOA?

Answer 3

inhibits sodium transport through ion channels in the cortical collecting tubule and late distal tubule

Question 4

potassium sparing diuretics (spironolactone/Eplerenone )side effects?

Answer 4

hyperkalemia
gynecomastia
constipation
hypotension
rash

Question 5

potassium sparing diuretics, amiloride, side effect?

Answer 5

hyperkalemia
headache
diarrhea
abdominal discomfort
decrease appetite
impotence

Question 6

potassium sparing diuretics, triamterene, side effect?

Answer 6

hyperkalemia
hyponatremia
GI disturbances
megaloblastic anemia

Question 7

indications for eplerenone?

Answer 7

hypertension

Question 8

spironolactone indicatons?

Answer 8

hypertension
primary aldosteronism
hypokalemia
edema secondary to cirrhosis***
heart failure

Question 9

amiloride indications?

Answer 9

hypkalemia

Question 10

triamterene indications?

Answer 10

hypokalemia

edema

Question 11

spironolactone/eplerenone contraindications?

Answer 11

hypersensitivity to spironolactone

moderate to severe renal dysfunction

hyperkalemia

Question 12

amiloride contraindications?

Answer 12

hyperkalemia

severe renal dysfunction

hypersensitivity to amiloride

moderate to severe hepatic dysfinction