2ND GEN DRUGS

Question 1

first line for schizophrenia

Answer 1

2nd gen antipsychotics

Question 2

most cardio metabolic side effects

Answer 2

olanzapine

Question 3

lowest cardiometabolic disturbances

QT prolongation risk (avoid if pt taking other drugs that prolong QT)

Answer 3

ziprasidone

Question 4

higher EPS and hyperprolactinemia potential when used at higher doses

moderate cardio metabolic side effects

Answer 4

risperidone

Question 5

active metabolite of risperidone (acts similar to risperidone)

Answer 5

paliperidone

Question 6

partial D2 agonism

low EPS potential and cardio metabolic side effects

Answer 6

aripiprazole

Question 7

must take with food
CYP3A4 substrate
preferred in preg (Cat B)

Answer 7

lurasidone

Question 8

QT prolongation

orthostatic hypotension that requires titration

Answer 8

Iloperidone

Question 9

sublingual absorption
hypoesthesia
dysgeusia

Answer 9

asenapine

Question 10

partial D2 agonism

low moderate cardio metabolic effects

Answer 10

brexpiprazole

Question 11

partial D2 and D3 agonism
low cardio metabolic effects
more EPS than other SGAs

Answer 11

cariprazine

Question 12

most efficacious, most side effects and used when other drugs fail

Answer 12

clozapine