ANTICOAGULANT MEDS Flashcards
1
Q
Platelet
- this drug by itself is not an anticoagulant, and needs
to bind to Antithrimbin III to become one - Unfractionated heparin inactivates factors IX, X, XI,
XII - LMWH have a greater effect on Factor Xa and less
on thrombin, whereas heparin have equal effects on thrombin and factor Xa - Monitor with PTT, since its intrinsic
- LMWH cleared renally, monitor with Anti Xa
A
Heparin (anti-coagulant)
2
Q
Platelet
- Affect factors II, VII, IX, X, which are part of the
extrinsic activation of clotting - Only drug for treating patients with mech valves at
home, but heparin in hospital - Amiodarone, ketoconazole, fluconazole and itraconazole inhibits warfarin metabolism***
A
Warfarin (anti-coagulant)
3
Q
Platelet
- Argatroban directly affects thrombin active site
- Bivalirudin, lepirudin, Hirudin, Refludin are other
direct thrombin inhibitors - Dabigatran is a factor IIa inhibitor that is not
metabolized by P450; do not open capsule because
it increases bioavailability by 75% - Antidote for dabigatran is idarucizumab***
A
Thrombin inhibitors (anti-coagulant) (-gatr, -rudin)
4
Q
Platelet
- Fondaparinux, Apixaban, Rivaroxaban inhibit Factor
Xa. If you take too much, take activated charcoal
within 2 hours - Factor Xa inhibitors are cleared by kidney
- Antidote for Apixaban or Rivaroxaban is andexanet
alpha*** - Avoid strong CYP3A4 inducers if patient is taking
Rivaroxaban or Apixaban - Monitor antifactor Xa for
fondaparinux***
A
Factor Xa Inhibitor
-parin
5
Q
Platelet
-Alteplase activates tissue plasminogen activator
which activates plasminogen to plasmin to break
clots
- Streptokinase combines with proactivator
plasminogen
- Urokinase directly converts plasminogen to active plasmin
A
Thrombolytic Agents
anti-coagulant
6
Q
Platelet
- Competitively inhibits plasminogen activation
A
Aminocaproic acid
7
Q
Platelet
- Inhibits plasmin, which is useful for reducing blood
loss in surgery
A
Aprotinin
