TB pharm - Exam 1B

Question 1

what class is Isoniazid (INH)

Answer 1

Antitubercular drug

Question 2

Isoniazid MOA

Answer 2

Disrupts cell wall synthesis essential functions of mycobacteria

Question 3

Isoniazid indication

Answer 3

First line TB med

Question 4

Isoniazid SE

Answer 4

Peripheral neuropathy, hepatotoxicity, optic neuritis/visual disturbance, hyperglycemia

Question 5

Isoniazid nursing considerations

Answer 5

BBW: increased risk of hepatitis (often given w/ vit B6)

Avoid antacids

When given with rifampin, can increase CNS & hepatotoxicity

If given w/ phenytoin, can increase phenytoin effect

Question 6

Rifampin MOA

Answer 6

Inhibits protein synthesis via attacking the hydrocarbon ring structure

Question 6

what class is Rifampin

Answer 6

Antitubercular drug

Question 7

Rifampin indications

Answer 7

Mycobacterial infections

meningitis, HIV

Question 8

Rifampin SE

Answer 8

Hepatitis, hematologic disorders, red/brown discoloration of the urine & other body fluids

Question 9

Rifampin nursing considerations

Answer 9

Lots of drug-drug interaction so consult HCP & pharm before taking (may need to increase dose of the other meds)

Question 10

what class is Ethambutol

Answer 10

Antitubercular drug

Question 11

Ethambutol MOA

Answer 11

Diffusing into the mycobacteria and suppresses RNA synthesis, which inhibits protein synthesis

Question 12

Ethambutol indication

Answer 12

First line bacteriostatic

Question 13

Ethambutol SE

Answer 13

Retrobulbar neuritis
Blindness

Question 14

Ethambutol nursing consideration

Answer 14

Usually given in combo with INH and rifampin

Not for children <13 yrs

Question 15

what class is Pyrazinamide

Answer 15

Antitubercular drug

Question 16

Pyrazinamide MOA

Answer 16

Unknown -> thought to inhibit lipid and nucleic acid synthesis

Question 17

Pyrazinamide indications

Answer 17

Bacteriostatic or bactericidal depending on drug concentration

Question 18

Pyrazinamide SE

Answer 18

Hepatotoxicity
Hyperuricemia

Question 19

Pyrazinamide nursing considerations

Answer 19

Contraindicated in severe hepatic disease or acute gout

Not for pregnant people in USA

Question 20

what class is Streptomycin

Answer 20

Antitubercular drug

Question 21

Streptomycin MOA

Answer 21

Aminoglycoside – interfering with normal protein synthesis causing production of faulty proteins within the bacteria

Question 22

Streptomycin indication

Answer 22

TB

Question 23

Streptomycin SE

Answer 23

Ototoxicity
Nephrotoxicity
Blood dyscrasias

Question 24

Streptomycin nursing considerations

Answer 24

can increase bleeding so careful with people on anticoags

given IM